Mitosin/CENP-F in mitosis, transcriptional control, and differentiation

Li Ma; Xiangshan Zhao; Xueliang Zhu

doi:10.1007/s11373-005-9057-3

Mitosin/CENP-F in mitosis, transcriptional control, and differentiation

Li Ma, Xiangshan Zhao, Xueliang Zhu

Genetics, Cell Biology & Anatomy

Research output: Contribution to journal › Review article › peer-review

39 Scopus citations

Abstract

Mitosin/CENP-F is a large nuclear/kinetochore protein containing multiple leucine zipper motifs potentially for protein interactions. Its expression levels and subcellular localization patterns are regulated in a cell cycle-dependent manner. Recently, accumulating lines of evidence have suggested it a multifunctional protein involved in mitotic control, microtubule dynamics, transcriptional regulation, and muscle cell differentiation. Consistently, it is shown to interact directly with a variety of proteins including CENP-E, NudE/Nudel, ATF4, and Rb. Here we review the current progress and discuss possible mechanisms through which mitosin may function.

Original language	English (US)
Pages (from-to)	205-213
Number of pages	9
Journal	Journal of Biomedical Science
Volume	13
Issue number	2
DOIs	https://doi.org/10.1007/s11373-005-9057-3
State	Published - Mar 2006

Keywords

Differentiation
Kinetochore
Mitosis
Transcription

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Molecular Biology
Clinical Biochemistry
Cell Biology
Biochemistry, medical
Pharmacology (medical)

Access to Document

10.1007/s11373-005-9057-3

Fingerprint Dive into the research topics of 'Mitosin/CENP-F in mitosis, transcriptional control, and differentiation'. Together they form a unique fingerprint.

Cite this

@article{3e13d2d2ea0e43eb9aacd3bcfa06fceb,

title = "Mitosin/CENP-F in mitosis, transcriptional control, and differentiation",

abstract = "Mitosin/CENP-F is a large nuclear/kinetochore protein containing multiple leucine zipper motifs potentially for protein interactions. Its expression levels and subcellular localization patterns are regulated in a cell cycle-dependent manner. Recently, accumulating lines of evidence have suggested it a multifunctional protein involved in mitotic control, microtubule dynamics, transcriptional regulation, and muscle cell differentiation. Consistently, it is shown to interact directly with a variety of proteins including CENP-E, NudE/Nudel, ATF4, and Rb. Here we review the current progress and discuss possible mechanisms through which mitosin may function.",

keywords = "Differentiation, Kinetochore, Mitosis, Transcription",

author = "Li Ma and Xiangshan Zhao and Xueliang Zhu",

note = "Funding Information: This work was supported by Grants No. 30330330 and 30421005 from Natural Science Foundation of China.",

year = "2006",

month = mar,

doi = "10.1007/s11373-005-9057-3",

language = "English (US)",

volume = "13",

pages = "205--213",

journal = "Journal of Biomedical Science",

issn = "1021-7770",

publisher = "BioMed Central",

number = "2",

}

TY - JOUR

T1 - Mitosin/CENP-F in mitosis, transcriptional control, and differentiation

AU - Ma, Li

AU - Zhao, Xiangshan

AU - Zhu, Xueliang

N1 - Funding Information: This work was supported by Grants No. 30330330 and 30421005 from Natural Science Foundation of China.

PY - 2006/3

Y1 - 2006/3

N2 - Mitosin/CENP-F is a large nuclear/kinetochore protein containing multiple leucine zipper motifs potentially for protein interactions. Its expression levels and subcellular localization patterns are regulated in a cell cycle-dependent manner. Recently, accumulating lines of evidence have suggested it a multifunctional protein involved in mitotic control, microtubule dynamics, transcriptional regulation, and muscle cell differentiation. Consistently, it is shown to interact directly with a variety of proteins including CENP-E, NudE/Nudel, ATF4, and Rb. Here we review the current progress and discuss possible mechanisms through which mitosin may function.

AB - Mitosin/CENP-F is a large nuclear/kinetochore protein containing multiple leucine zipper motifs potentially for protein interactions. Its expression levels and subcellular localization patterns are regulated in a cell cycle-dependent manner. Recently, accumulating lines of evidence have suggested it a multifunctional protein involved in mitotic control, microtubule dynamics, transcriptional regulation, and muscle cell differentiation. Consistently, it is shown to interact directly with a variety of proteins including CENP-E, NudE/Nudel, ATF4, and Rb. Here we review the current progress and discuss possible mechanisms through which mitosin may function.

KW - Differentiation

KW - Kinetochore

KW - Mitosis

KW - Transcription

UR - http://www.scopus.com/inward/record.url?scp=33645356427&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645356427&partnerID=8YFLogxK

U2 - 10.1007/s11373-005-9057-3

DO - 10.1007/s11373-005-9057-3

M3 - Review article

C2 - 16456711

AN - SCOPUS:33645356427

VL - 13

SP - 205

EP - 213

JO - Journal of Biomedical Science

JF - Journal of Biomedical Science

SN - 1021-7770

IS - 2

ER -

Mitosin/CENP-F in mitosis, transcriptional control, and differentiation

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this