Abstract
Mitosin/CENP-F is a large nuclear/kinetochore protein containing multiple leucine zipper motifs potentially for protein interactions. Its expression levels and subcellular localization patterns are regulated in a cell cycle-dependent manner. Recently, accumulating lines of evidence have suggested it a multifunctional protein involved in mitotic control, microtubule dynamics, transcriptional regulation, and muscle cell differentiation. Consistently, it is shown to interact directly with a variety of proteins including CENP-E, NudE/Nudel, ATF4, and Rb. Here we review the current progress and discuss possible mechanisms through which mitosin may function.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 205-213 |
| Number of pages | 9 |
| Journal | Journal of Biomedical Science |
| Volume | 13 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 2006 |
Keywords
- Differentiation
- Kinetochore
- Mitosis
- Transcription
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Molecular Biology
- Clinical Biochemistry
- Cell Biology
- Biochemistry, medical
- Pharmacology (medical)
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Ma, L., Zhao, X., & Zhu, X. (2006). Mitosin/CENP-F in mitosis, transcriptional control, and differentiation. Journal of Biomedical Science, 13(2), 205-213. https://doi.org/10.1007/s11373-005-9057-3