Mitosin/CENP-F in mitosis, transcriptional control, and differentiation

Li Ma, Xiangshan Zhao, Xueliang Zhu

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations


Mitosin/CENP-F is a large nuclear/kinetochore protein containing multiple leucine zipper motifs potentially for protein interactions. Its expression levels and subcellular localization patterns are regulated in a cell cycle-dependent manner. Recently, accumulating lines of evidence have suggested it a multifunctional protein involved in mitotic control, microtubule dynamics, transcriptional regulation, and muscle cell differentiation. Consistently, it is shown to interact directly with a variety of proteins including CENP-E, NudE/Nudel, ATF4, and Rb. Here we review the current progress and discuss possible mechanisms through which mitosin may function.

Original languageEnglish (US)
Pages (from-to)205-213
Number of pages9
JournalJournal of Biomedical Science
Issue number2
StatePublished - Mar 2006
Externally publishedYes


  • Differentiation
  • Kinetochore
  • Mitosis
  • Transcription

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology
  • Biochemistry, medical
  • Pharmacology (medical)


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