Modality of bacterial growth presents unique targets: How do we treat biofilm-mediated infections?

Research output: Contribution to journalReview articlepeer-review

87 Scopus citations

Abstract

It is well accepted that bacterial pathogens growing in a biofilm are recalcitrant to the action of most antibiotics and are resistant to the innate immune system. New treatment modalities are greatly warranted to effectively eradicate these infections. However, bacteria growing in a biofilm are metabolically unique in comparison to the bacteria growing in a planktonic state. Unfortunately, most antibiotics have been developed to inhibit the growth of bacteria in a planktonic mode of growth. This review focuses on the metabolism and physiology of biofilm growth with special emphasis on staphylococci. Future treatment options should include targeting unique metabolic niches found within bacterial biofilms in addition to the enzymes or compounds that inhibit biofilm accumulation molecules and/or interact with quorum sensing and intercellular bacterial communication.

Original languageEnglish (US)
Pages (from-to)610-615
Number of pages6
JournalCurrent Opinion in Microbiology
Volume13
Issue number5
DOIs
StatePublished - Oct 2010

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases

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