Model systems for assessing cognitive function: Implications for HIV-1 infection and drugs of abuse

W. E. Zink; J. Boyle; Y. Persidsky; H. Xiong; H. E. Gendelman

Model systems for assessing cognitive function: Implications for HIV-1 infection and drugs of abuse

W. E. Zink, J. Boyle, Y. Persidsky, H. Xiong, H. E. Gendelman

Research output: Contribution to journal › Article › peer-review

Abstract

Memory deficits are common among drug abusers and in those with chronic neurodegenerative disorders. Currently, the mechanisms through which diverse neurophysiologic processes alter memory are not known. This review describes the current systems and rationale for studying memory formation, consolidation, and recall. Special attention is given to physiologic (hippocampal long-term potentiation) and behavioral animal models. The principles and methods described can be applied to studies of diverse clinical disorders.

Original language	English (US)
Pages (from-to)	7-27
Number of pages	21
Journal	Advances in experimental medicine and biology
Volume	493
State	Published - 2001

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Cite this

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abstract = "Memory deficits are common among drug abusers and in those with chronic neurodegenerative disorders. Currently, the mechanisms through which diverse neurophysiologic processes alter memory are not known. This review describes the current systems and rationale for studying memory formation, consolidation, and recall. Special attention is given to physiologic (hippocampal long-term potentiation) and behavioral animal models. The principles and methods described can be applied to studies of diverse clinical disorders.",

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AB - Memory deficits are common among drug abusers and in those with chronic neurodegenerative disorders. Currently, the mechanisms through which diverse neurophysiologic processes alter memory are not known. This review describes the current systems and rationale for studying memory formation, consolidation, and recall. Special attention is given to physiologic (hippocampal long-term potentiation) and behavioral animal models. The principles and methods described can be applied to studies of diverse clinical disorders.

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Model systems for assessing cognitive function: Implications for HIV-1 infection and drugs of abuse

Abstract

ASJC Scopus subject areas

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