Modeling Diffusion and Chemical Reactions to Analyze Redox-Based Molecular-Electrical Communication

Karthik Reddy Gorla, Tyler Barker, Massimiliano Pierobon

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

For more than a decade, Molecular Communication (MC), inspired by the natural way biological cells communicate, has been studied in engineering as the key paradigm for realizing computing and information systems increasingly integrated with biology. Broad application scenarios range from medical diagnostics and treatment, to biocompatible device and systems engineering. This paper focuses on a recently proposed technology able to transduce information from the MC domain to the electrical domain of classical circuits and systems. In particular, this is based on redox reactions, i. e., chemical processes where molecules exchange electrons, which play an important role in living systems. Based on these processes and a proof-of-concept prototype realized by our research collaborators, this paper addresses the computational modeling necessary to derive the design principles of such system. In particular, a stochastic simulation framework is developed to reproduce the transduction of information signals from the MC (input molecule concentration) to the electrical domain (output current). Numerical results from this framework, realized in MATLAB, are presented to evaluate the Signal-toNoise Ratio (SNR), the Limit of Detection (LOD), and the Limit of Quantification (LOQ) of this transduction process as a function of the input concentration value. While at its preliminary stage, this framework has the potential to be foundational towards the engineering of a complete redox-based bio-hybrid electronics.

Original languageEnglish (US)
Title of host publication2020 IEEE International Conference on Communications, ICC 2020 - Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781728150895
DOIs
StatePublished - Jun 2020
Event2020 IEEE International Conference on Communications, ICC 2020 - Dublin, Ireland
Duration: Jun 7 2020Jun 11 2020

Publication series

NameIEEE International Conference on Communications
Volume2020-June
ISSN (Print)1550-3607

Conference

Conference2020 IEEE International Conference on Communications, ICC 2020
CountryIreland
CityDublin
Period6/7/206/11/20

Keywords

  • Chemical noise
  • Cyclic voltammetry
  • Diffusion noise
  • Molecular communication
  • Redox channel

ASJC Scopus subject areas

  • Computer Networks and Communications
  • Electrical and Electronic Engineering

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  • Cite this

    Gorla, K. R., Barker, T., & Pierobon, M. (2020). Modeling Diffusion and Chemical Reactions to Analyze Redox-Based Molecular-Electrical Communication. In 2020 IEEE International Conference on Communications, ICC 2020 - Proceedings [9148750] (IEEE International Conference on Communications; Vol. 2020-June). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ICC40277.2020.9148750