Modeling the tumor microenvironment using chitosan-alginate scaffolds to control the stem-like state of glioblastoma cells

Forrest M. Kievit, Kui Wang, Ariane E. Erickson, Sheeny K. Lan Levengood, Richard G. Ellenbogen, Miqin Zhang

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Better prediction of in vivo drug efficacy using in vitro models should greatly improve in vivo success. Here we utilize 3D highly porous chitosan-alginate complex scaffolds to probe how various components of the glioblastoma microenvironment including extracellular matrix and stromal cells affect tumor cell stem-like state.

Original languageEnglish (US)
Pages (from-to)610-613
Number of pages4
JournalBiomaterials Science
Volume4
Issue number4
DOIs
StatePublished - Apr 2016
Externally publishedYes

ASJC Scopus subject areas

  • Biomedical Engineering
  • Materials Science(all)

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