Models of breast cancer

Laurice A. Matulka, Kay Uwe Wagner

Research output: Contribution to journalReview article

13 Scopus citations

Abstract

The intention of this review is to provide a succinct overview about the availability and relevance of the major categories of mouse models for breast cancer. The review concentrates on the latest achievements in developing genetically engineered mice with conditional knockout alleles or models that allow the inducible expression of oncogenes in mammary epithelial cells. In particular, we discuss the applicability of these models for drug target validation. Furthermore, we critically evaluate experimental designs for modeling cancer prevention and therapeutic intervention by genetic means in vivo.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalDrug Discovery Today: Disease Models
Volume2
Issue number1
DOIs
StatePublished - Jul 18 2005
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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