@article{6dbd4440443a46dcb4407f8b77f9b763,
title = "Modification of pancreatic carcinogenesis in the hamster model. XV. preventive effect of nicotinamide",
abstract = "The induction of pancreatic ductal-ductular adenomas (P=.05) and carcinomas (P<.0001) by N-nitrosobis(2-oxopropyl)amine [(BOP) CAS: 60599-38-4; 2, 2′-dioxo-N-nitrosodipropylamine] in Syrian golden hamsters was inhibited by nicotinamide (NA) (350 mg/kg body wt, ip) administered 10 minutes before and 3 hours after a single dose of BOP (10 mg/kg body wt, sc). The anticancer effect of NA and its relatively low toxicity in humans may provide a new lead in human cancer prevention.",
author = "Pour, {Parviz M.} and Terence Lawson",
note = "Funding Information: I Received March 5, 1984; accepted May 18, 1984. 2 Supported by Public Health Service grant R26CA-20198-06 from the National Pancreatic Cancer Project, Division of Cancer Cause and Prevention, National Cancer Institute. 3 Animals were maintained under the guidelines set forth in the {"}Guide for the Care and Use of Laboratory Animals{"} by the Institute of Laboratory Animals Resources, National Research Council. 4The Eppley Institute for Research in Cancer and Allied Diseases, The University of Nebraska Medical Center, 42d St. and Dewey Ave., Omaha, Nebr. 68105. S Department of Pathology and Laboratory Medicine, The University of Nebraska Medical Center.",
year = "1984",
month = jan,
day = "1",
doi = "10.1093/jnci/73.3.767",
language = "English (US)",
volume = "73",
pages = "767--770",
journal = "Journal of the National Cancer Institute",
issn = "0027-8874",
publisher = "Oxford University Press",
number = "3",
}