Modification of pancreatic carcinogenesis in the hamster model. XV. preventive effect of nicotinamide

Parviz M. Pour, Terence Lawson

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The induction of pancreatic ductal-ductular adenomas (P=.05) and carcinomas (P<.0001) by N-nitrosobis(2-oxopropyl)amine [(BOP) CAS: 60599-38-4; 2, 2′-dioxo-N-nitrosodipropylamine] in Syrian golden hamsters was inhibited by nicotinamide (NA) (350 mg/kg body wt, ip) administered 10 minutes before and 3 hours after a single dose of BOP (10 mg/kg body wt, sc). The anticancer effect of NA and its relatively low toxicity in humans may provide a new lead in human cancer prevention.

Original languageEnglish (US)
Pages (from-to)767-770
Number of pages4
JournalJournal of the National Cancer Institute
Volume73
Issue number3
DOIs
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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