Abstract
The acute and chronic effects of estradiol benzoate were studied on apomorphine-induced climbing behavior in intact female mice. Climbing behavior was measured by determining the maximum climbing time and climbing index. Mice pretreated with estradiol benzoate (0.1 or 0.3 mg/kg, SC) for 3.5 or 24 hours prior to apomorphine administration showed no significant difference in climbing behavior when compared to corn oil-treated controls. However, mice pretreated with estradiol benzoate (0.1 mg/kg, SC) for 3 consecutive days showed an attenuation in apomorphine-induced climbing at 24 or 72 hours after the last steroid injection. This study shows that the mouse climbing behavioral model provides a simple and quantitative procedure for studying the antidopaminergic effects of estrogen.
Original language | English (US) |
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Pages (from-to) | 139-141 |
Number of pages | 3 |
Journal | Pharmacology, Biochemistry and Behavior |
Volume | 24 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1986 |
Keywords
- Climbing behavior
- Dopamine
- Estradiol
ASJC Scopus subject areas
- Biochemistry
- Toxicology
- Pharmacology
- Clinical Biochemistry
- Biological Psychiatry
- Behavioral Neuroscience