Modulation of apomorphine-induced climbing behavior by estradiol

Y. K. Fung, Robert W. Brueggemeier, Norman J. Uretsky

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The acute and chronic effects of estradiol benzoate were studied on apomorphine-induced climbing behavior in intact female mice. Climbing behavior was measured by determining the maximum climbing time and climbing index. Mice pretreated with estradiol benzoate (0.1 or 0.3 mg/kg, SC) for 3.5 or 24 hours prior to apomorphine administration showed no significant difference in climbing behavior when compared to corn oil-treated controls. However, mice pretreated with estradiol benzoate (0.1 mg/kg, SC) for 3 consecutive days showed an attenuation in apomorphine-induced climbing at 24 or 72 hours after the last steroid injection. This study shows that the mouse climbing behavioral model provides a simple and quantitative procedure for studying the antidopaminergic effects of estrogen.

Original languageEnglish (US)
Pages (from-to)139-141
Number of pages3
JournalPharmacology, Biochemistry and Behavior
Volume24
Issue number1
DOIs
StatePublished - Jan 1986

Keywords

  • Climbing behavior
  • Dopamine
  • Estradiol

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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