Modulation of C-myc by transforming growth factor-β in human colon carcinoma cells

Kathleen M. Mulder, Alan E. Levine, Xochil Hernandez, Mary K. McKnight, Diane E. Brattain, Michael G. Brattain

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

Previous work indicated that transforming growth factor-β elicits proliferation-inhibitory and differentiation-like effects in the human colon carcinoma cell line MOSER. We report for the first time that the proto-oncogene c-myc is repressed in response to transforming growth factor-β in a human colon carcinoma cell line. We also describe a subline of these cells which are relatively resistant to the transforming growth factor-β-induced effects on proliferation in monolayer and in soft agarose, but which retain the ability to specifically bind transforming growth factor-β. Analysis of molecular and cellular alterations in this subline may aid in elucidating the mechanism of action of transforming growth factor-β.

Original languageEnglish (US)
Pages (from-to)711-716
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume150
Issue number2
DOIs
StatePublished - Jan 29 1988

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Mulder, K. M., Levine, A. E., Hernandez, X., McKnight, M. K., Brattain, D. E., & Brattain, M. G. (1988). Modulation of C-myc by transforming growth factor-β in human colon carcinoma cells. Biochemical and Biophysical Research Communications, 150(2), 711-716. https://doi.org/10.1016/0006-291X(88)90449-4