Abstract
Previous work indicated that transforming growth factor-β elicits proliferation-inhibitory and differentiation-like effects in the human colon carcinoma cell line MOSER. We report for the first time that the proto-oncogene c-myc is repressed in response to transforming growth factor-β in a human colon carcinoma cell line. We also describe a subline of these cells which are relatively resistant to the transforming growth factor-β-induced effects on proliferation in monolayer and in soft agarose, but which retain the ability to specifically bind transforming growth factor-β. Analysis of molecular and cellular alterations in this subline may aid in elucidating the mechanism of action of transforming growth factor-β.
Original language | English (US) |
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Pages (from-to) | 711-716 |
Number of pages | 6 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 150 |
Issue number | 2 |
DOIs | |
State | Published - Jan 29 1988 |
Externally published | Yes |
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology