Modulation of cellular phosphoprotein profiles in transformation and redifferentiation of murine AKR embryonic fibroblastic cells

Subhas Chakrabarty, Michael G. Brattain

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Cellular phosphoprotein profiles from normal mouse embryonic fibroblast AKR-2B cells were compared to those of their permanently, chemically transformed malignant counterparts AKR-MCA cells, and AKR-2B cells reversibly transformed by transforming growth factor (AKR-TGF). Similar 32P-phosphorylation profiles were observed for both the AKR-TGF and AKR-MCA cells which were distinct from that of the normal AKR-2B cells. Dimethylformamide (DMF)-induced differentiation of the AKR-MCA cells resulted in a restoration of the normal AKR-2B phosphorylation profile to the malignant AKR-MCA cells.

Original languageEnglish (US)
Pages (from-to)151-155
Number of pages5
JournalCancer Letters
Volume29
Issue number2
DOIs
StatePublished - Nov 1985

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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