Modulation of Cellular Response to Arsenic Trioxide Toxicity by Resveratrol

Bodhisattwa Mondal; Hongxia Chen; Weihua Wen; Ercole L. Cavalieri; Eleanor G. Rogan; Muhammad Zahid

doi:10.1021/acsomega.7b01727

Modulation of Cellular Response to Arsenic Trioxide Toxicity by Resveratrol

Bodhisattwa Mondal, Hongxia Chen, Weihua Wen, Ercole L. Cavalieri, Eleanor G. Rogan, Muhammad Zahid

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Arsenic trioxide (As₂O₃) is an environmental carcinogen and a putative endocrine disruptor. Resveratrol has been shown to reverse As₂O₃-induced oxidative damage. In immortalized but nontransformed estrogen receptor α-negative human breast cells (MCF10A), we observed that 25 μM resveratrol ameliorated As₂O₃-induced cytotoxicity. As₂O₃, in the presence or absence of 25 μM resveratrol, induced quinone reductase (NAD(P)H quinone dehydrogenase 1), via the induction of NFE2-related factor 2. As₂O₃ caused a repression of cytochrome P450 (CYP)1B1, but the addition of 25 μM resveratrol rescued the expression of cytochrome P450 1B1 and kept it at a constant level. Therefore, 25 μM resveratrol can modulate the effects of As₂O₃ on enzymes involved in estrogen metabolism.

Original language	English (US)
Pages (from-to)	5511-5515
Number of pages	5
Journal	ACS Omega
Volume	3
Issue number	5
DOIs	https://doi.org/10.1021/acsomega.7b01727
State	Published - May 21 2018

ASJC Scopus subject areas

General Chemistry
General Chemical Engineering

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title = "Modulation of Cellular Response to Arsenic Trioxide Toxicity by Resveratrol",

abstract = "Arsenic trioxide (As2O3) is an environmental carcinogen and a putative endocrine disruptor. Resveratrol has been shown to reverse As2O3-induced oxidative damage. In immortalized but nontransformed estrogen receptor α-negative human breast cells (MCF10A), we observed that 25 μM resveratrol ameliorated As2O3-induced cytotoxicity. As2O3, in the presence or absence of 25 μM resveratrol, induced quinone reductase (NAD(P)H quinone dehydrogenase 1), via the induction of NFE2-related factor 2. As2O3 caused a repression of cytochrome P450 (CYP)1B1, but the addition of 25 μM resveratrol rescued the expression of cytochrome P450 1B1 and kept it at a constant level. Therefore, 25 μM resveratrol can modulate the effects of As2O3 on enzymes involved in estrogen metabolism.",

author = "Bodhisattwa Mondal and Hongxia Chen and Weihua Wen and Cavalieri, {Ercole L.} and Rogan, {Eleanor G.} and Muhammad Zahid",

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T1 - Modulation of Cellular Response to Arsenic Trioxide Toxicity by Resveratrol

AU - Mondal, Bodhisattwa

AU - Chen, Hongxia

AU - Wen, Weihua

AU - Cavalieri, Ercole L.

AU - Rogan, Eleanor G.

AU - Zahid, Muhammad

PY - 2018/5/21

Y1 - 2018/5/21

N2 - Arsenic trioxide (As2O3) is an environmental carcinogen and a putative endocrine disruptor. Resveratrol has been shown to reverse As2O3-induced oxidative damage. In immortalized but nontransformed estrogen receptor α-negative human breast cells (MCF10A), we observed that 25 μM resveratrol ameliorated As2O3-induced cytotoxicity. As2O3, in the presence or absence of 25 μM resveratrol, induced quinone reductase (NAD(P)H quinone dehydrogenase 1), via the induction of NFE2-related factor 2. As2O3 caused a repression of cytochrome P450 (CYP)1B1, but the addition of 25 μM resveratrol rescued the expression of cytochrome P450 1B1 and kept it at a constant level. Therefore, 25 μM resveratrol can modulate the effects of As2O3 on enzymes involved in estrogen metabolism.

AB - Arsenic trioxide (As2O3) is an environmental carcinogen and a putative endocrine disruptor. Resveratrol has been shown to reverse As2O3-induced oxidative damage. In immortalized but nontransformed estrogen receptor α-negative human breast cells (MCF10A), we observed that 25 μM resveratrol ameliorated As2O3-induced cytotoxicity. As2O3, in the presence or absence of 25 μM resveratrol, induced quinone reductase (NAD(P)H quinone dehydrogenase 1), via the induction of NFE2-related factor 2. As2O3 caused a repression of cytochrome P450 (CYP)1B1, but the addition of 25 μM resveratrol rescued the expression of cytochrome P450 1B1 and kept it at a constant level. Therefore, 25 μM resveratrol can modulate the effects of As2O3 on enzymes involved in estrogen metabolism.

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Modulation of Cellular Response to Arsenic Trioxide Toxicity by Resveratrol

Abstract

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