TY - JOUR
T1 - Modulation of Cellular Response to Arsenic Trioxide Toxicity by Resveratrol
AU - Mondal, Bodhisattwa
AU - Chen, Hongxia
AU - Wen, Weihua
AU - Cavalieri, Ercole L.
AU - Rogan, Eleanor G.
AU - Zahid, Muhammad
N1 - Funding Information:
*E-mail: mzahid@unmc.edu. Phone: 1-402-559-8912. Fax: 1-402-559-7259. ORCID Muhammad Zahid: 0000-0002-9975-9476 Author Contributions The manuscript was written through contributions of all authors. Funding This project was supported by an internal grant of the University of Nebraska Medical Center, awarded and administered by the College of Public Health, UNMC, Omaha, NE. Core support at the Eppley Institute was provided by grant P30 CA36727 from the National Cancer Institute at the National Institutes of Health. Notes The authors declare no competing financial interest.
Publisher Copyright:
Copyright © 2018 American Chemical Society.
PY - 2018/5/21
Y1 - 2018/5/21
N2 - Arsenic trioxide (As2O3) is an environmental carcinogen and a putative endocrine disruptor. Resveratrol has been shown to reverse As2O3-induced oxidative damage. In immortalized but nontransformed estrogen receptor α-negative human breast cells (MCF10A), we observed that 25 μM resveratrol ameliorated As2O3-induced cytotoxicity. As2O3, in the presence or absence of 25 μM resveratrol, induced quinone reductase (NAD(P)H quinone dehydrogenase 1), via the induction of NFE2-related factor 2. As2O3 caused a repression of cytochrome P450 (CYP)1B1, but the addition of 25 μM resveratrol rescued the expression of cytochrome P450 1B1 and kept it at a constant level. Therefore, 25 μM resveratrol can modulate the effects of As2O3 on enzymes involved in estrogen metabolism.
AB - Arsenic trioxide (As2O3) is an environmental carcinogen and a putative endocrine disruptor. Resveratrol has been shown to reverse As2O3-induced oxidative damage. In immortalized but nontransformed estrogen receptor α-negative human breast cells (MCF10A), we observed that 25 μM resveratrol ameliorated As2O3-induced cytotoxicity. As2O3, in the presence or absence of 25 μM resveratrol, induced quinone reductase (NAD(P)H quinone dehydrogenase 1), via the induction of NFE2-related factor 2. As2O3 caused a repression of cytochrome P450 (CYP)1B1, but the addition of 25 μM resveratrol rescued the expression of cytochrome P450 1B1 and kept it at a constant level. Therefore, 25 μM resveratrol can modulate the effects of As2O3 on enzymes involved in estrogen metabolism.
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U2 - 10.1021/acsomega.7b01727
DO - 10.1021/acsomega.7b01727
M3 - Article
C2 - 29876539
AN - SCOPUS:85047424916
VL - 3
SP - 5511
EP - 5515
JO - ACS Omega
JF - ACS Omega
SN - 2470-1343
IS - 5
ER -