Modulation of steroid production in goat ovarian cells: Effect of progestins and antiprogestins

Surender M. Kharbanda, V. Band, K. Murugesan, A. Farooq

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Effect of various synthetic progestins and antiprogestational compounds on progesterone (P) and estradiol (E) production by isolated goat ovarian granulosa (G) and corpus luteum (CL) cell types was studied in vitro. Steroid production was studied either under basal conditions or after stimulation with follicle stimulating hormone (FSH) in the presence of aromatase substrate, androstenedione (A). None of the progestins had any significant effect on basal P and E production by either cell types during 48 hour of culture. The FSH and A - induced increase in P and E production was significantly inhibited following concommitant treatment with synthetic progestins at concentrations higher than 10-7M. The added progestins had no effect on G and CL cell viability. None of the antiprogestational compounds had any significant effect on basal steroid production in either of the cell types. Furthermore, the higher concentrations of three antiprogestins namely RMI 14156, STS 557 and isomer 201 of RMI

Original languageEnglish (US)
Pages (from-to)293-309
Number of pages17
JournalEndocrine Research
Volume16
Issue number2
DOIs
StatePublished - 1990

ASJC Scopus subject areas

  • Endocrinology

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