Molecular aspects of COVID-19 differential pathogenesis

Hussin A. Rothan, Arpan Acharya, St Patrick Reid, Mukesh Kumar, Siddappa N. Byrareddy

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

In the absence of therapeutic interventions, and a possible vaccine candidate, the spread of COVID-19 disease and associated fatalities are on the rise. The high mutation frequency in the genomic material of these viruses supports their ability to adapt to new environments, resulting in an efficient alteration in tissue tropism and host range. Therefore, the coronavirus’ health threats could be relevant for the long-term. The epidemiological data indicate that age, sex, and cardio-metabolic disease have a significant impact on the spread and severity of COVID-19. In this review, we highlight recent updates on the pathogenesis of SARS-CoV-2 among men and women, including children. We also discuss the role of the cellular receptors and coreceptors used by the virus to enter host cells on differential infection among men, women, and cardio-metabolic patients.

Original languageEnglish (US)
Article number538
Pages (from-to)1-9
Number of pages9
JournalPathogens
Volume9
Issue number7
DOIs
StatePublished - Jul 2020

Keywords

  • COVID-19
  • Cardio-metabolic disease
  • Comorbidity
  • Differential pathogenesis
  • SARS-COV-2

ASJC Scopus subject areas

  • Immunology and Allergy
  • Molecular Biology
  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

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