TY - JOUR
T1 - Molecular aspects of COVID-19 differential pathogenesis
AU - Rothan, Hussin A.
AU - Acharya, Arpan
AU - Reid, St Patrick
AU - Kumar, Mukesh
AU - Byrareddy, Siddappa N.
N1 - Funding Information:
Funding: This work is partially supported by the National Institute of Allergy and Infectious Diseases Grant R01 AI129745 and P30MH062261 to S.N.B., Frances E. Lageschulte, and Evelyn B. Weese.; New Frontiers in Medical Research Fund to S.N.B./S.P.R.; grant (R21NS099838) from National Institute of Neurological Disorders and Stroke, grant (R21OD024896) from the Office of the Director to M.K.
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2020/7
Y1 - 2020/7
N2 - In the absence of therapeutic interventions, and a possible vaccine candidate, the spread of COVID-19 disease and associated fatalities are on the rise. The high mutation frequency in the genomic material of these viruses supports their ability to adapt to new environments, resulting in an efficient alteration in tissue tropism and host range. Therefore, the coronavirus’ health threats could be relevant for the long-term. The epidemiological data indicate that age, sex, and cardio-metabolic disease have a significant impact on the spread and severity of COVID-19. In this review, we highlight recent updates on the pathogenesis of SARS-CoV-2 among men and women, including children. We also discuss the role of the cellular receptors and coreceptors used by the virus to enter host cells on differential infection among men, women, and cardio-metabolic patients.
AB - In the absence of therapeutic interventions, and a possible vaccine candidate, the spread of COVID-19 disease and associated fatalities are on the rise. The high mutation frequency in the genomic material of these viruses supports their ability to adapt to new environments, resulting in an efficient alteration in tissue tropism and host range. Therefore, the coronavirus’ health threats could be relevant for the long-term. The epidemiological data indicate that age, sex, and cardio-metabolic disease have a significant impact on the spread and severity of COVID-19. In this review, we highlight recent updates on the pathogenesis of SARS-CoV-2 among men and women, including children. We also discuss the role of the cellular receptors and coreceptors used by the virus to enter host cells on differential infection among men, women, and cardio-metabolic patients.
KW - COVID-19
KW - Cardio-metabolic disease
KW - Comorbidity
KW - Differential pathogenesis
KW - SARS-COV-2
UR - http://www.scopus.com/inward/record.url?scp=85087552770&partnerID=8YFLogxK
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U2 - 10.3390/pathogens9070538
DO - 10.3390/pathogens9070538
M3 - Review article
C2 - 32640525
AN - SCOPUS:85087552770
SN - 2076-0817
VL - 9
SP - 1
EP - 9
JO - Pathogens
JF - Pathogens
IS - 7
M1 - 538
ER -