Molecular aspects of COVID-19 differential pathogenesis

Hussin A. Rothan, Arpan Acharya, St Patrick Reid, Mukesh Kumar, Siddappa N. Byrareddy

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


In the absence of therapeutic interventions, and a possible vaccine candidate, the spread of COVID-19 disease and associated fatalities are on the rise. The high mutation frequency in the genomic material of these viruses supports their ability to adapt to new environments, resulting in an efficient alteration in tissue tropism and host range. Therefore, the coronavirus’ health threats could be relevant for the long-term. The epidemiological data indicate that age, sex, and cardio-metabolic disease have a significant impact on the spread and severity of COVID-19. In this review, we highlight recent updates on the pathogenesis of SARS-CoV-2 among men and women, including children. We also discuss the role of the cellular receptors and coreceptors used by the virus to enter host cells on differential infection among men, women, and cardio-metabolic patients.

Original languageEnglish (US)
Article number538
Pages (from-to)1-9
Number of pages9
Issue number7
StatePublished - Jul 2020


  • COVID-19
  • Cardio-metabolic disease
  • Comorbidity
  • Differential pathogenesis
  • SARS-COV-2

ASJC Scopus subject areas

  • Immunology and Allergy
  • Molecular Biology
  • General Immunology and Microbiology
  • Microbiology (medical)
  • Infectious Diseases


Dive into the research topics of 'Molecular aspects of COVID-19 differential pathogenesis'. Together they form a unique fingerprint.

Cite this