TY - JOUR
T1 - Molecular basis of cell cycle dependent HIV-1 replication
T2 - Implications for control of virus burden
AU - Stevenson, M.
AU - Brichacek, B.
AU - Heinzinger, N.
AU - Swindells, S.
AU - Pirruccello, S.
AU - Janoff, E.
AU - Emerman, M.
PY - 1995
Y1 - 1995
N2 - Research is beginning to yield insight into determinants which govern cell cycle dependence of provirus establishment by the onco-retroviruses. In the case of HIV-1, nucleophilic components associated with the viral preintegration complex facilitate mitosis independent nuclear localization of viral DNA and provirus establishment. Differences in the metabolic activity between G0 T cells and macrophages, the two primary targets for HIV-1 infection, lead to significantly different outcomes with regards to provirus establishment following infection of these cells. Thus, macrophages appear fully permissive to productive HIV-1 replication while non-dividing (G0 T cells) restrict virus replication at a step which proceeds nuclear import of viral DNA. The requirement for T cell activation in productive HIV-1 replication has important implications for the relationship between immune activation and virus burden. It remains to be determined whether modulating the immune activation status of the infected individual may provide an opportunity for modulating virus burden and influencing disease course.
AB - Research is beginning to yield insight into determinants which govern cell cycle dependence of provirus establishment by the onco-retroviruses. In the case of HIV-1, nucleophilic components associated with the viral preintegration complex facilitate mitosis independent nuclear localization of viral DNA and provirus establishment. Differences in the metabolic activity between G0 T cells and macrophages, the two primary targets for HIV-1 infection, lead to significantly different outcomes with regards to provirus establishment following infection of these cells. Thus, macrophages appear fully permissive to productive HIV-1 replication while non-dividing (G0 T cells) restrict virus replication at a step which proceeds nuclear import of viral DNA. The requirement for T cell activation in productive HIV-1 replication has important implications for the relationship between immune activation and virus burden. It remains to be determined whether modulating the immune activation status of the infected individual may provide an opportunity for modulating virus burden and influencing disease course.
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U2 - 10.1007/978-1-4615-1995-9_4
DO - 10.1007/978-1-4615-1995-9_4
M3 - Review article
C2 - 7572399
AN - SCOPUS:0029031254
SN - 0065-2598
VL - 374
SP - 33
EP - 45
JO - Advances in experimental medicine and biology
JF - Advances in experimental medicine and biology
ER -