Molecular classification of the peripheral T-cell lymphomas

Tyler A. Herek, Javeed Iqbal

Research output: Chapter in Book/Report/Conference proceedingChapter


Molecular classification of peripheral T-cell Lymphomas (PTCLs) provides vital information about the maturation, activation state, and molecular pathogenesis of PTCL entities. To understand the development of PTCL, it is essential to trace T-cell development, which briefly describes T-lymphocyte generation and activation. Non-Hodgkin lymphomas (NHL) derived from the T and natural killer (NK) cell lineage represent a highly heterogeneous subset of malignancies with varied morphological and clinical features. They typically comprise about 15-20% of all NHLs in the Western world. The World Health Organization currently recognizes at least 29 entities with angioimmunoblastic T-cell lymphoma, anaplastic large-cell lymphoma, adult T-cell leukemia/lymphoma, extranodal NK/T-cell lymphoma, nasal type, and PTCL-NOS, representing approximately 80% of all diagnoses. Molecular classifications can be adapted from gene expression signatures into modalities more suited for future clinical use.

Original languageEnglish (US)
Title of host publicationThe Peripheral T-Cell Lymphomas
Number of pages13
ISBN (Electronic)9781119671336
ISBN (Print)9781119671312
StatePublished - Feb 19 2021


  • Anaplastic large-cell lymphoma
  • Angioimmunoblastic T-cell lymphoma
  • Gene expression
  • Molecular classification
  • Molecular pathogenesis
  • Non-Hodgkin lymphomas
  • Peripheral T-cell lymphomas
  • T-cell development

ASJC Scopus subject areas

  • Medicine(all)


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