Abstract
Currently, the gold standards for the diagnosis and treatment of hematopoietic malignancies remain the morphologic features, karyotype and flow cytometric analysis. However, the time to correlate these standard-bearers with molecular diagnostic testing is upon us. Molecular biological techniques have, in fact, revolutionized the diagnosis and management of a wide variety of medical disorders, and have had a major impact on all medical disciplines, particularly hematology. Hematology already greatly relies on specialized molecular procedures for the diagnosis and management of patients. Molecular-genetic testing is anticipated to result in improved cytoreduction, as well as increased cure rates for these patients in the near future.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 172-191 |
| Number of pages | 20 |
| Journal | Journal of Clinical Ligand Assay |
| Volume | 24 |
| Issue number | 3 |
| State | Published - 2001 |
| Externally published | Yes |
Keywords
- Comparative genomic hybridization (CGH)
- Cytogenetics
- Fluorescence immunophenotyping and interphase cytogenetics as a tool for investigation of neoplasms (FICTION)
- Fluorescence in situ hybridization (FISH)
- Leukemia
- Lymphoma
- Microarray
- Molecular
- Polymerase chain reaction (PCR)
- Serial analysis of gene expression (SAGE)
ASJC Scopus subject areas
- Clinical Biochemistry
- Biochemistry, medical