Molecular remodeling in the failing human heart.

Dee Ann M. Rivera, Brian D. Lowes

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Heart failure is a progressive and fatal disease process. Arrhythmias and progressive cardiac dysfunction account for most of the morbidity and mortality in patients with heart failure. In general, the physiologic mechanisms responsible for progressive myocyte dysfunction, remodeling, and arrhythmias involve signaling mechanisms that alter myocardial gene expression. These changes in gene expression are complex and involve contractile proteins, ion channels, Ca++ handling, apoptosis, cell metabolism, the extracellular matrix, signal transduction pathways, and growth factors.

Original languageEnglish (US)
Pages (from-to)5-9
Number of pages5
JournalCurrent heart failure reports
Issue number1
StatePublished - Mar 2005
Externally publishedYes

ASJC Scopus subject areas

  • Emergency Medicine
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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