Abstract
Breast cancer (BC) is one of the most frequently diagnosed cancers in women worldwide. It has surpassed lung cancer as the leading cause of cancer-related death. Breast cancer brain metastasis (BCBM) is becoming a major clinical concern that is commonly associated with ER-ve and HER2+ve subtypes of BC patients. Metastatic lesions in the brain originate when the cancer cells detach from a primary breast tumor and establish metastatic lesions and infiltrate near and distant organs via systemic blood circulation by traversing the BBB. The colonization of BC cells in the brain involves a complex interplay in the tumor microenvironment (TME), metastatic cells, and brain cells like endothelial cells, microglia, and astrocytes. BCBM is a significant cause of morbidity and mortality and presents a challenge to developing successful cancer therapy. In this review, we discuss the molecular mechanism of BCBM and novel therapeutic strategies for patients with brain metastatic BC.
Original language | English (US) |
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Article number | 100079 |
Journal | Advances in Cancer Biology - Metastasis |
Volume | 7 |
DOIs | |
State | Published - Jul 2023 |
Keywords
- Blood-brain barrier
- Brain metastasis
- Breast cancer
- Signaling pathways
- Targeted therapies
ASJC Scopus subject areas
- Cancer Research
- Cell Biology