Molecular signaling network and therapeutic developments in breast cancer brain metastasis

Mercilena Benjamin, Pushkar Malakar, Rohit Anthony Sinha, Mohd Wasim Nasser, Surinder K. Batra, Jawed Akhtar Siddiqui, Bandana Chakravarti

Research output: Contribution to journalReview articlepeer-review


Breast cancer (BC) is one of the most frequently diagnosed cancers in women worldwide. It has surpassed lung cancer as the leading cause of cancer-related death. Breast cancer brain metastasis (BCBM) is becoming a major clinical concern that is commonly associated with ER-ve and HER2+ve subtypes of BC patients. Metastatic lesions in the brain originate when the cancer cells detach from a primary breast tumor and establish metastatic lesions and infiltrate near and distant organs via systemic blood circulation by traversing the BBB. The colonization of BC cells in the brain involves a complex interplay in the tumor microenvironment (TME), metastatic cells, and brain cells like endothelial cells, microglia, and astrocytes. BCBM is a significant cause of morbidity and mortality and presents a challenge to developing successful cancer therapy. In this review, we discuss the molecular mechanism of BCBM and novel therapeutic strategies for patients with brain metastatic BC.

Original languageEnglish (US)
Article number100079
JournalAdvances in Cancer Biology - Metastasis
StatePublished - Jul 2023


  • Blood-brain barrier
  • Brain metastasis
  • Breast cancer
  • Signaling pathways
  • Targeted therapies

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology


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