Molecular targets for modulating lung inflammation and injury

Ruxana T. Sadikot, J. W. Christman, T. S. Blackwell

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations

Abstract

The inflammatory response of the lung and airways is one of the main targets for the development of new therapies for variety of disorders including the acute respiratory distress syndrome, cystic fibrosis, idiopathic pulmonary fibrosis, and chronic obstructive pulmonary disease. Over the last decade our understanding of the molecular biology of the inflammatory response has advanced considerably and has opened up new avenues for therapeutic intervention. Furthermore, the mechanism of action of many of the existing anti-inflammatory agents has been revealed by this burgeoning information. Here, we discuss the functions and therapeutic potential of molecules that might prove promising as targets for treatment of inflammatory lung diseases. These possible molecular targets include cell surface proteins/receptors Itoll like receptors (TLRs), triggering receptors expressed on myeloid cells (TREMs), and syndecans)], transcription factors INF-KB, AP-1, PUA, and high mobility group box I (HMGBI)], and regulatory proteins [macrophage migration inhibitory factor (MIF), granulocyte macrophage colony stimulating factor (GM-CSF), cyclooxygenase 2 (COX-2), herne oxygenase 1 (HO-1).

Original languageEnglish (US)
Pages (from-to)581-588
Number of pages8
JournalCurrent drug targets
Volume5
Issue number6
DOIs
StatePublished - Aug 2004
Externally publishedYes

Keywords

  • Acute respiratory distress syndrome
  • AP-1
  • GM-CSF
  • HMGB-1
  • HO-1
  • Macrophage
  • MIF
  • NF-κB
  • PU.1
  • Syndecans
  • TLR
  • TREM

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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