Molecules to modeling: Toxoplasma gondii oocysts at the human-animal-environment interface

Elizabeth VanWormer; Heather Fritz; Karen Shapiro; Jonna A.K. Mazet; Patricia A. Conrad

doi:10.1016/j.cimid.2012.10.006

Molecules to modeling: Toxoplasma gondii oocysts at the human-animal-environment interface

Elizabeth VanWormer, Heather Fritz, Karen Shapiro, Jonna A.K. Mazet, Patricia A. Conrad

Research output: Contribution to journal › Review article › peer-review

79 Scopus citations

Abstract

Environmental transmission of extremely resistant Toxoplasma gondii oocysts has resulted in infection of diverse species around the world, leading to severe disease and deaths in human and animal populations. This review explores T. gondii oocyst shedding, survival, and transmission, emphasizing the importance of linking laboratory and landscape from molecular characterization of oocysts to watershed-level models of oocyst loading and transport in terrestrial and aquatic systems. Building on discipline-specific studies, a One Health approach incorporating tools and perspectives from diverse fields and stakeholders has contributed to an advanced understanding of T. gondii and is addressing transmission at the rapidly changing human-animal-environment interface.

Original language	English (US)
Pages (from-to)	217-231
Number of pages	15
Journal	Comparative Immunology, Microbiology and Infectious Diseases
Volume	36
Issue number	3
DOIs	https://doi.org/10.1016/j.cimid.2012.10.006
State	Published - May 2013
Externally published	Yes

Keywords

Climate change
Environmental resistance
Land use change
Modeling
Molecular characterization
One Health
Oocyst
Toxoplasma gondii
Transport
Zoonotic disease

ASJC Scopus subject areas

Microbiology
Immunology and Allergy
Immunology
General Veterinary
Infectious Diseases

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10.1016/j.cimid.2012.10.006

Cite this

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title = "Molecules to modeling: Toxoplasma gondii oocysts at the human-animal-environment interface",

abstract = "Environmental transmission of extremely resistant Toxoplasma gondii oocysts has resulted in infection of diverse species around the world, leading to severe disease and deaths in human and animal populations. This review explores T. gondii oocyst shedding, survival, and transmission, emphasizing the importance of linking laboratory and landscape from molecular characterization of oocysts to watershed-level models of oocyst loading and transport in terrestrial and aquatic systems. Building on discipline-specific studies, a One Health approach incorporating tools and perspectives from diverse fields and stakeholders has contributed to an advanced understanding of T. gondii and is addressing transmission at the rapidly changing human-animal-environment interface.",

keywords = "Climate change, Environmental resistance, Land use change, Modeling, Molecular characterization, One Health, Oocyst, Toxoplasma gondii, Transport, Zoonotic disease",

author = "Elizabeth VanWormer and Heather Fritz and Karen Shapiro and Mazet, {Jonna A.K.} and Conrad, {Patricia A.}",

note = "Funding Information: Funding sources supporting the authors included NSF-Ecology of Infectious Disease Grants ( 0525765 , 1065990 ), a National Institutes of Health K01 award ( 5K01RR031487 ) to H. Fritz, and a fellowship from the National Oceanic and Atmospheric Administration Oceans and Human Health Initiative ( S08-67884 ) to K. Shapiro. The authors thank Alison Kent, UC Davis Wildlife Health Center, for assistance in developing the transmission graphic.",

year = "2013",

month = may,

doi = "10.1016/j.cimid.2012.10.006",

language = "English (US)",

volume = "36",

pages = "217--231",

journal = "Comparative Immunology, Microbiology and Infectious Diseases",

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AU - VanWormer, Elizabeth

AU - Fritz, Heather

AU - Shapiro, Karen

AU - Mazet, Jonna A.K.

AU - Conrad, Patricia A.

N1 - Funding Information: Funding sources supporting the authors included NSF-Ecology of Infectious Disease Grants ( 0525765 , 1065990 ), a National Institutes of Health K01 award ( 5K01RR031487 ) to H. Fritz, and a fellowship from the National Oceanic and Atmospheric Administration Oceans and Human Health Initiative ( S08-67884 ) to K. Shapiro. The authors thank Alison Kent, UC Davis Wildlife Health Center, for assistance in developing the transmission graphic.

PY - 2013/5

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AB - Environmental transmission of extremely resistant Toxoplasma gondii oocysts has resulted in infection of diverse species around the world, leading to severe disease and deaths in human and animal populations. This review explores T. gondii oocyst shedding, survival, and transmission, emphasizing the importance of linking laboratory and landscape from molecular characterization of oocysts to watershed-level models of oocyst loading and transport in terrestrial and aquatic systems. Building on discipline-specific studies, a One Health approach incorporating tools and perspectives from diverse fields and stakeholders has contributed to an advanced understanding of T. gondii and is addressing transmission at the rapidly changing human-animal-environment interface.

KW - Climate change

KW - Environmental resistance

KW - Land use change

KW - Modeling

KW - Molecular characterization

KW - One Health

KW - Oocyst

KW - Toxoplasma gondii

KW - Transport

KW - Zoonotic disease

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JO - Comparative Immunology, Microbiology and Infectious Diseases

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Molecules to modeling: Toxoplasma gondii oocysts at the human-animal-environment interface

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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