Mom1 is a semi-dominant modifier of intestinal adenoma size and multiplicity in Min/+ mice

Karen A. Gould; William F. Dietrich; Natalie Borenstein; Eric S. Lander; William F. Dove

Mom1 is a semi-dominant modifier of intestinal adenoma size and multiplicity in Min/+ mice

Karen A. Gould, William F. Dietrich, Natalie Borenstein, Eric S. Lander, William F. Dove

Research output: Contribution to journal › Article › peer-review

Abstract

The intestinal multiplicity in mice heterozygous for Apc(Min) is strongly modulated by genetic background. On the sensitive C57BL/6J (B6) background, mice develop large numbers of intestinal adenomas. The AKR/J (AKR) strain carries alleles that correlate with a strong reduction in tumor multiplicity. To study the effect of one of these modifiers, Mom1, we have generated a mouse line in which the AKR allele of Mom1 is carried on the sensitive B6 genetic background. This strain was produced by using a marker- assisted selection method to eliminate unlinked AKR alleles more rapidly. The application and efficacy of this are discussed. We used this strain to determine that Mom1 affects both tumor multiplicity and tumor size in a semi- domain fashion.

Original language	English (US)
Pages (from-to)	1769-1776
Number of pages	8
Journal	Genetics
Volume	144
Issue number	4
State	Published - Dec 1996
Externally published	Yes

ASJC Scopus subject areas

Genetics

Cite this

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title = "Mom1 is a semi-dominant modifier of intestinal adenoma size and multiplicity in Min/+ mice",

abstract = "The intestinal multiplicity in mice heterozygous for Apc(Min) is strongly modulated by genetic background. On the sensitive C57BL/6J (B6) background, mice develop large numbers of intestinal adenomas. The AKR/J (AKR) strain carries alleles that correlate with a strong reduction in tumor multiplicity. To study the effect of one of these modifiers, Mom1, we have generated a mouse line in which the AKR allele of Mom1 is carried on the sensitive B6 genetic background. This strain was produced by using a marker- assisted selection method to eliminate unlinked AKR alleles more rapidly. The application and efficacy of this are discussed. We used this strain to determine that Mom1 affects both tumor multiplicity and tumor size in a semi- domain fashion.",

author = "Gould, {Karen A.} and Dietrich, {William F.} and Natalie Borenstein and Lander, {Eric S.} and Dove, {William F.}",

year = "1996",

month = dec,

language = "English (US)",

volume = "144",

pages = "1769--1776",

journal = "Genetics",

issn = "0016-6731",

publisher = "Oxford University Press",

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T1 - Mom1 is a semi-dominant modifier of intestinal adenoma size and multiplicity in Min/+ mice

AU - Gould, Karen A.

AU - Dietrich, William F.

AU - Borenstein, Natalie

AU - Lander, Eric S.

AU - Dove, William F.

PY - 1996/12

Y1 - 1996/12

N2 - The intestinal multiplicity in mice heterozygous for Apc(Min) is strongly modulated by genetic background. On the sensitive C57BL/6J (B6) background, mice develop large numbers of intestinal adenomas. The AKR/J (AKR) strain carries alleles that correlate with a strong reduction in tumor multiplicity. To study the effect of one of these modifiers, Mom1, we have generated a mouse line in which the AKR allele of Mom1 is carried on the sensitive B6 genetic background. This strain was produced by using a marker- assisted selection method to eliminate unlinked AKR alleles more rapidly. The application and efficacy of this are discussed. We used this strain to determine that Mom1 affects both tumor multiplicity and tumor size in a semi- domain fashion.

AB - The intestinal multiplicity in mice heterozygous for Apc(Min) is strongly modulated by genetic background. On the sensitive C57BL/6J (B6) background, mice develop large numbers of intestinal adenomas. The AKR/J (AKR) strain carries alleles that correlate with a strong reduction in tumor multiplicity. To study the effect of one of these modifiers, Mom1, we have generated a mouse line in which the AKR allele of Mom1 is carried on the sensitive B6 genetic background. This strain was produced by using a marker- assisted selection method to eliminate unlinked AKR alleles more rapidly. The application and efficacy of this are discussed. We used this strain to determine that Mom1 affects both tumor multiplicity and tumor size in a semi- domain fashion.

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Mom1 is a semi-dominant modifier of intestinal adenoma size and multiplicity in Min/+ mice

Abstract

ASJC Scopus subject areas

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