Monitoring of Ebola virus Makona evolution through establishment of advanced genomic capability in Liberia

US Army Medical Research Institute of Infectious Diseases and National Institutes of Health/Integrated Research Facility-Frederick Ebola Response Team 2014-2015

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

To support Liberia’s response to the ongoing Ebola virus (EBOV) disease epidemic in Western Africa, we established in-country advanced genomic capabilities to monitor EBOV evolution. Twenty-five EBOV genomes were sequenced at the Liberian Institute for Biomedical Research, which provided an in-depth view of EBOV diversity in Liberia during September 2014–February 2015. These sequences were consistent with a single virus introduction to Liberia; however, shared ancestry with isolates from Mali indicated at least 1 additional instance of movement into or out of Liberia. The pace of change is generally consistent with previous estimates of mutation rate. We observed 23 nonsynonymous mutations and 1 nonsense mutation. Six of these changes are within known binding sites for sequence-based EBOV medical countermeasures; however, the diagnostic and therapeutic impact of EBOV evolution within Liberia appears to be low.

Original languageEnglish (US)
Pages (from-to)1135-1143
Number of pages9
JournalEmerging infectious diseases
Volume21
Issue number7
DOIs
StatePublished - 2015

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

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    US Army Medical Research Institute of Infectious Diseases and National Institutes of Health/Integrated Research Facility-Frederick Ebola Response Team 2014-2015 (2015). Monitoring of Ebola virus Makona evolution through establishment of advanced genomic capability in Liberia. Emerging infectious diseases, 21(7), 1135-1143. https://doi.org/10.3201/eid2107.150522