Monitoring of smokeless tobacco consumers using cytogenetic endpoints

A. H. Trivedi, B. J. Dave, S. G. Adhvaryu

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Smokeless tobacco consumption is causally associated with oral cavity cancers; however extensive cytogenetic studies have not been done. In the present study individuals consuming dry snuff or tobacco with lime have been studied for frequency of micronucleated cells (MNC) in exfoliated buccal mucosa and chromosome aberrations (CA) and sister chromatid exchanges (SCE) in lymphocytes. The significant elevation in the values of all the three cytogenetic markers among tobacco users compared to the controls reveal the extent of genomic damage on target and nontarget tissues. The findings emphasize the possible use of cytogenetic endpoints for monitoring smokeless tobacco consumers.

Original languageEnglish (US)
Pages (from-to)2245-2249
Number of pages5
JournalAnticancer Research
Volume13
Issue number6 A
StatePublished - 1993
Externally publishedYes

Keywords

  • Buccal mucosa cells
  • Cancer of oral cavity
  • Chromosome aberration
  • Human lymphocytes
  • Micronucleus
  • Sister chromatid exchange
  • Snuff
  • Tobacco plus lime chewing

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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