TY - JOUR
T1 - Monoamine oxidase inhibitors. Synthesis of a series of isopropylidine and isopropyl derivatives of some aryl and arylalkyl acid hydrazides
AU - Weinswig, M. H.
AU - Roche, E. B.
PY - 1965/8
Y1 - 1965/8
N2 - Six isopropylidene hydrazides and six isopropyl hydrazides were prepared. This investigation was undertaken since recent derivatives of hydrazines and hydrazides have shown considerable activity as monoamine oxidase inhibitors. The hydrazides were synthesized from the aryl and arylalkylesters and hydrazine. From these hydrazides the isopropylidene derivatives were prepared by refluxing with acetone. Reduction of the isopropylidene hydrazides, using hydrogen and 5 per cent platinum‐on‐charcoal catalyst, gave the isopropyl hydrazides. The hydrazides prepared were of benzoic acid, phenylacetic acid, α‐naphthoic acid, β‐naphthoic acid, α‐naphthylacetic acid, and β‐naphthylacetic acid.
AB - Six isopropylidene hydrazides and six isopropyl hydrazides were prepared. This investigation was undertaken since recent derivatives of hydrazines and hydrazides have shown considerable activity as monoamine oxidase inhibitors. The hydrazides were synthesized from the aryl and arylalkylesters and hydrazine. From these hydrazides the isopropylidene derivatives were prepared by refluxing with acetone. Reduction of the isopropylidene hydrazides, using hydrogen and 5 per cent platinum‐on‐charcoal catalyst, gave the isopropyl hydrazides. The hydrazides prepared were of benzoic acid, phenylacetic acid, α‐naphthoic acid, β‐naphthoic acid, α‐naphthylacetic acid, and β‐naphthylacetic acid.
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U2 - 10.1002/jps.2600540831
DO - 10.1002/jps.2600540831
M3 - Article
C2 - 5882236
AN - SCOPUS:0013795162
SN - 0022-3549
VL - 54
SP - 1216
EP - 1218
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
IS - 8
ER -