Monoamine oxidase inhibitors. Synthesis of a series of isopropylidine and isopropyl derivatives of some aryl and arylalkyl acid hydrazides

M. H. Weinswig, E. B. Roche

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Six isopropylidene hydrazides and six isopropyl hydrazides were prepared. This investigation was undertaken since recent derivatives of hydrazines and hydrazides have shown considerable activity as monoamine oxidase inhibitors. The hydrazides were synthesized from the aryl and arylalkylesters and hydrazine. From these hydrazides the isopropylidene derivatives were prepared by refluxing with acetone. Reduction of the isopropylidene hydrazides, using hydrogen and 5 per cent platinum‐on‐charcoal catalyst, gave the isopropyl hydrazides. The hydrazides prepared were of benzoic acid, phenylacetic acid, α‐naphthoic acid, β‐naphthoic acid, α‐naphthylacetic acid, and β‐naphthylacetic acid.

Original languageEnglish (US)
Pages (from-to)1216-1218
Number of pages3
JournalJournal of Pharmaceutical Sciences
Volume54
Issue number8
DOIs
StatePublished - Aug 1965

ASJC Scopus subject areas

  • Pharmaceutical Science

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