Montmorillonite-Alginate nanocomposites as a drug delivery system: Intercalation and in vitro release of vitamin B1 and vitamin B 6

Bhavesh D. Kevadiya; Ghanshyam V. Joshi; Hasmukh A. Patel; Pravin G. Ingole; Haresh M. Mody; Hari C. Bajaj

doi:10.1177/0885328209344003

Montmorillonite-Alginate nanocomposites as a drug delivery system: Intercalation and in vitro release of vitamin B₁ and vitamin B ₆

Bhavesh D. Kevadiya, Ghanshyam V. Joshi, Hasmukh A. Patel, Pravin G. Ingole, Haresh M. Mody, Hari C. Bajaj

Research output: Contribution to journal › Article › peer-review

87 Scopus citations

Abstract

Sustained intestinal delivery of thiamine hydrochloride (Vitamin B ₁; VB₁) and pyridoxine hydrochloride (Vitamin B ₆; VB₆) seems to be a feasible alternative to existing therapy. The vitamins (VB₁/VB₆) intercalated in montmorillonite (MMT) and intercalated VB₁/VB₆-MMT hybrid is further used for synthesis of VB₁/VB₆-MMT-alginate nanocomposite beads by gelation method and in vitro release in the intestinal environment. The structure and surface morphology of the synthesized VB ₁/VB₆-MMT hybrid, VB₁/VB₆-alginate and VB₁/VB₆-MMT-alginate nanocomposite beads were characterized by XRD, FT-IR, TGA and SEM. In vitro release experiments revealed that the VB₁/VB₆ releases suddenly from VB ₁/VB₆-MMT hybrid and is pH dependent. The controlled release of VB₁/VB₆ from VB₁/VB ₆-MMT-alginate nanocomposite beads was observed to be controlled as compared to their release from VB₁/VB₆-MMT hybrid and VB₁/VB₆-alginate beads.

Original language	English (US)
Pages (from-to)	161-177
Number of pages	17
Journal	Journal of Biomaterials Applications
Volume	25
Issue number	2
DOIs	https://doi.org/10.1177/0885328209344003
State	Published - Aug 2010
Externally published	Yes

Keywords

alginate
montmorillonite
nanocomposites
pyridoxine hydrochloride
thiamine hydrochloride

ASJC Scopus subject areas

Biomaterials
Biomedical Engineering

Access to Document

10.1177/0885328209344003

Cite this

@article{56e6fc577a1148f5bc55dd20c762f7b9,

title = "Montmorillonite-Alginate nanocomposites as a drug delivery system: Intercalation and in vitro release of vitamin B1 and vitamin B 6",

abstract = "Sustained intestinal delivery of thiamine hydrochloride (Vitamin B 1; VB1) and pyridoxine hydrochloride (Vitamin B 6; VB6) seems to be a feasible alternative to existing therapy. The vitamins (VB1/VB6) intercalated in montmorillonite (MMT) and intercalated VB1/VB6-MMT hybrid is further used for synthesis of VB1/VB6-MMT-alginate nanocomposite beads by gelation method and in vitro release in the intestinal environment. The structure and surface morphology of the synthesized VB 1/VB6-MMT hybrid, VB1/VB6-alginate and VB1/VB6-MMT-alginate nanocomposite beads were characterized by XRD, FT-IR, TGA and SEM. In vitro release experiments revealed that the VB1/VB6 releases suddenly from VB 1/VB6-MMT hybrid and is pH dependent. The controlled release of VB1/VB6 from VB1/VB 6-MMT-alginate nanocomposite beads was observed to be controlled as compared to their release from VB1/VB6-MMT hybrid and VB1/VB6-alginate beads.",

keywords = "alginate, montmorillonite, nanocomposites, pyridoxine hydrochloride, thiamine hydrochloride",

author = "Kevadiya, {Bhavesh D.} and Joshi, {Ghanshyam V.} and Patel, {Hasmukh A.} and Ingole, {Pravin G.} and Mody, {Haresh M.} and Bajaj, {Hari C.}",

year = "2010",

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doi = "10.1177/0885328209344003",

language = "English (US)",

volume = "25",

pages = "161--177",

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T2 - Intercalation and in vitro release of vitamin B1 and vitamin B 6

AU - Kevadiya, Bhavesh D.

AU - Joshi, Ghanshyam V.

AU - Patel, Hasmukh A.

AU - Ingole, Pravin G.

AU - Mody, Haresh M.

AU - Bajaj, Hari C.

PY - 2010/8

Y1 - 2010/8

N2 - Sustained intestinal delivery of thiamine hydrochloride (Vitamin B 1; VB1) and pyridoxine hydrochloride (Vitamin B 6; VB6) seems to be a feasible alternative to existing therapy. The vitamins (VB1/VB6) intercalated in montmorillonite (MMT) and intercalated VB1/VB6-MMT hybrid is further used for synthesis of VB1/VB6-MMT-alginate nanocomposite beads by gelation method and in vitro release in the intestinal environment. The structure and surface morphology of the synthesized VB 1/VB6-MMT hybrid, VB1/VB6-alginate and VB1/VB6-MMT-alginate nanocomposite beads were characterized by XRD, FT-IR, TGA and SEM. In vitro release experiments revealed that the VB1/VB6 releases suddenly from VB 1/VB6-MMT hybrid and is pH dependent. The controlled release of VB1/VB6 from VB1/VB 6-MMT-alginate nanocomposite beads was observed to be controlled as compared to their release from VB1/VB6-MMT hybrid and VB1/VB6-alginate beads.

AB - Sustained intestinal delivery of thiamine hydrochloride (Vitamin B 1; VB1) and pyridoxine hydrochloride (Vitamin B 6; VB6) seems to be a feasible alternative to existing therapy. The vitamins (VB1/VB6) intercalated in montmorillonite (MMT) and intercalated VB1/VB6-MMT hybrid is further used for synthesis of VB1/VB6-MMT-alginate nanocomposite beads by gelation method and in vitro release in the intestinal environment. The structure and surface morphology of the synthesized VB 1/VB6-MMT hybrid, VB1/VB6-alginate and VB1/VB6-MMT-alginate nanocomposite beads were characterized by XRD, FT-IR, TGA and SEM. In vitro release experiments revealed that the VB1/VB6 releases suddenly from VB 1/VB6-MMT hybrid and is pH dependent. The controlled release of VB1/VB6 from VB1/VB 6-MMT-alginate nanocomposite beads was observed to be controlled as compared to their release from VB1/VB6-MMT hybrid and VB1/VB6-alginate beads.

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