Montmorillonite-Alginate nanocomposites as a drug delivery system: Intercalation and in vitro release of vitamin B1 and vitamin B 6

Bhavesh D. Kevadiya, Ghanshyam V. Joshi, Hasmukh A. Patel, Pravin G. Ingole, Haresh M. Mody, Hari C. Bajaj

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

Sustained intestinal delivery of thiamine hydrochloride (Vitamin B 1; VB1) and pyridoxine hydrochloride (Vitamin B 6; VB6) seems to be a feasible alternative to existing therapy. The vitamins (VB1/VB6) intercalated in montmorillonite (MMT) and intercalated VB1/VB6-MMT hybrid is further used for synthesis of VB1/VB6-MMT-alginate nanocomposite beads by gelation method and in vitro release in the intestinal environment. The structure and surface morphology of the synthesized VB 1/VB6-MMT hybrid, VB1/VB6-alginate and VB1/VB6-MMT-alginate nanocomposite beads were characterized by XRD, FT-IR, TGA and SEM. In vitro release experiments revealed that the VB1/VB6 releases suddenly from VB 1/VB6-MMT hybrid and is pH dependent. The controlled release of VB1/VB6 from VB1/VB 6-MMT-alginate nanocomposite beads was observed to be controlled as compared to their release from VB1/VB6-MMT hybrid and VB1/VB6-alginate beads.

Original languageEnglish (US)
Pages (from-to)161-177
Number of pages17
JournalJournal of Biomaterials Applications
Volume25
Issue number2
DOIs
StatePublished - Aug 2010

Keywords

  • alginate
  • montmorillonite
  • nanocomposites
  • pyridoxine hydrochloride
  • thiamine hydrochloride

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering

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