Montmorillonite intercalated with vitamin B1 as drug carrier

Ghanshyam V. Joshi, Hasmukh A. Patel, Bhavesh D. Kevadiya, Hari C. Bajaj

Research output: Contribution to journalArticlepeer-review

131 Scopus citations


Vitamin B1 (thiamine hydrochloride, VB1) intercalated into montmorillonite (MMT), which was characterized by X-ray diffraction (XRD), Fourier transformed infrared spectroscopy (FT-IR), and thermo gravimetric analysis (TGA). The adsorption of VB1 on MMT increased with increase in reaction temperature. The adsorption isotherms were fitted by the Langmuir model. About 34 and 64% of the intercalated VB1 was released within 10 h, in simulated gastric fluid (pH 1.2) and simulated intestinal fluid (pH 7.4) respectively at 37 ± 0.5 °C. The release profile of VB1 followed the Higuchi kinetic model and the diffusion-controlled mechanism. During in vitro release experiments VB1 was released from MMT-VB1 steadily as a function of pH.

Original languageEnglish (US)
Pages (from-to)248-253
Number of pages6
JournalApplied Clay Science
Issue number4
StatePublished - Aug 2009
Externally publishedYes


  • In vitro release
  • Intercalation
  • Montmorillonite
  • Thiamine hydrochloride

ASJC Scopus subject areas

  • Geology
  • Geochemistry and Petrology

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