Montmorillonite Poly-L-lactide microcomposites of procainamide for controlled drug delivery: In vitro and in vivo evaluation

B. D. Kevadiya, T. K. Patel, Parvati B. Patel, Shalini Rajkumar, C. B. Tripathi, H. C. Bajaj

Research output: Contribution to journalArticle

Abstract

The research work reported in this paper is extension of our previous findings related to intercalation of procainamide hydrochloride, an antiarrythmia drug in interlayer gallery of Na + -clay (montmorillonite). The microcomposite particles prepared from procainamide-montmorillonite hybrid and poly L-lactide were characterised by scanning electron microscope and atomic force microscopy analysis. In vitro drug release study in simulated intestinal fluid showed controlled release pattern up to ~72 h and significant reduction in the drug release in gastric environment. In vivo pharmacokinetics and biodistribution in rats showed that the plasma/tissue drug levels were within therapeutic window as compared with free drug. The data from toxicity biomarker estimations and clinical biochemistry/haematological parameters showed significant reduction in drug toxicity when formulated in montmorillonite/poly L-lactide as compared with free drug, which is of considerable value in achieving improved therapy with reduced side effects.

Original languageEnglish (US)
Pages (from-to)722-726
Number of pages5
JournalIndian Journal of Pharmaceutical Sciences
Volume75
Issue number6
StatePublished - Nov 2013

Keywords

  • Antiarrythmia
  • controlled release
  • microcomposites
  • procainamide
  • toxicity biomarker

ASJC Scopus subject areas

  • Pharmaceutical Science

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