Montmorillonite/Poly (L-Lactide) microcomposite spheres as reservoirs of antidepressant drugs and their controlled release property

Shalini Rajkumar; Bhavesh D. Kevadiya; Hari C. Bajaj

doi:10.1016/j.ajps.2015.06.002

Montmorillonite/Poly (L-Lactide) microcomposite spheres as reservoirs of antidepressant drugs and their controlled release property

Shalini Rajkumar, Bhavesh D. Kevadiya, Hari C. Bajaj

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

This work evaluates intercalation of Nortriptyline (NT) and Venlafaxine (VFX) in an interlayer gallery of Na⁺-MMT (Montmorillonite), which was further compounded with Poly (L-Lactide) (PLLA) to form microcomposite spheres (MPs) for oral controlled drug delivery. The XRD patterns, thermal and spectroscopic analyses indicated intercalation of drugs into the MMT interlayer that was stabilized by electrostatic interaction. No significant changes in structural and functional properties of drugs were found in the MMT layers. In vitro drug release studies showed controlled release pattern.

Original language	English (US)
Pages (from-to)	452-458
Number of pages	7
Journal	Asian Journal of Pharmaceutical Sciences
Volume	10
Issue number	5
DOIs	https://doi.org/10.1016/j.ajps.2015.06.002
State	Published - Oct 1 2015
Externally published	Yes

Keywords

Antidepressant
Montmorillonite
Nortriptyline
Poly (L-Lactide)
Venlafaxine

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

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10.1016/j.ajps.2015.06.002

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title = "Montmorillonite/Poly (L-Lactide) microcomposite spheres as reservoirs of antidepressant drugs and their controlled release property",

abstract = "This work evaluates intercalation of Nortriptyline (NT) and Venlafaxine (VFX) in an interlayer gallery of Na+-MMT (Montmorillonite), which was further compounded with Poly (L-Lactide) (PLLA) to form microcomposite spheres (MPs) for oral controlled drug delivery. The XRD patterns, thermal and spectroscopic analyses indicated intercalation of drugs into the MMT interlayer that was stabilized by electrostatic interaction. No significant changes in structural and functional properties of drugs were found in the MMT layers. In vitro drug release studies showed controlled release pattern.",

keywords = "Antidepressant, Montmorillonite, Nortriptyline, Poly (L-Lactide), Venlafaxine",

author = "Shalini Rajkumar and Kevadiya, {Bhavesh D.} and Bajaj, {Hari C.}",

note = "Funding Information: Authors are thankful to Director, CSMCRI, Bhavnagar for providing necessary infrastructure facilities and the Council of Scientific and Industrial Research, Government of India, New Delhi, India ( CSIR ) for Senior research fellowship awarded to BDK, and funding under Network Project: NWP 0010 . Authors are also thankful for the help and cooperation rendered by Dr. Harshad Brahmbhatt (HPLC), Mr. V. Agarwal (FT-IR), Mr. Jayesh C. Chaudhari (SEM) and Mrs. Sheetal Patel (TGA) of the analytical section of the CSMCRI. Publisher Copyright: {\textcopyright} 2015 The Authors.",

year = "2015",

month = oct,

day = "1",

doi = "10.1016/j.ajps.2015.06.002",

language = "English (US)",

volume = "10",

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publisher = "Shenyang Pharmaceutical University",

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AU - Rajkumar, Shalini

AU - Kevadiya, Bhavesh D.

AU - Bajaj, Hari C.

N1 - Funding Information: Authors are thankful to Director, CSMCRI, Bhavnagar for providing necessary infrastructure facilities and the Council of Scientific and Industrial Research, Government of India, New Delhi, India ( CSIR ) for Senior research fellowship awarded to BDK, and funding under Network Project: NWP 0010 . Authors are also thankful for the help and cooperation rendered by Dr. Harshad Brahmbhatt (HPLC), Mr. V. Agarwal (FT-IR), Mr. Jayesh C. Chaudhari (SEM) and Mrs. Sheetal Patel (TGA) of the analytical section of the CSMCRI. Publisher Copyright: © 2015 The Authors.

PY - 2015/10/1

Y1 - 2015/10/1

N2 - This work evaluates intercalation of Nortriptyline (NT) and Venlafaxine (VFX) in an interlayer gallery of Na+-MMT (Montmorillonite), which was further compounded with Poly (L-Lactide) (PLLA) to form microcomposite spheres (MPs) for oral controlled drug delivery. The XRD patterns, thermal and spectroscopic analyses indicated intercalation of drugs into the MMT interlayer that was stabilized by electrostatic interaction. No significant changes in structural and functional properties of drugs were found in the MMT layers. In vitro drug release studies showed controlled release pattern.

AB - This work evaluates intercalation of Nortriptyline (NT) and Venlafaxine (VFX) in an interlayer gallery of Na+-MMT (Montmorillonite), which was further compounded with Poly (L-Lactide) (PLLA) to form microcomposite spheres (MPs) for oral controlled drug delivery. The XRD patterns, thermal and spectroscopic analyses indicated intercalation of drugs into the MMT interlayer that was stabilized by electrostatic interaction. No significant changes in structural and functional properties of drugs were found in the MMT layers. In vitro drug release studies showed controlled release pattern.

KW - Antidepressant

KW - Montmorillonite

KW - Nortriptyline

KW - Poly (L-Lactide)

KW - Venlafaxine

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DO - 10.1016/j.ajps.2015.06.002

M3 - Article

AN - SCOPUS:84944160390

SN - 1818-0876

VL - 10

SP - 452

EP - 458

JO - Asian Journal of Pharmaceutical Sciences

JF - Asian Journal of Pharmaceutical Sciences

IS - 5

ER -

Montmorillonite/Poly (L-Lactide) microcomposite spheres as reservoirs of antidepressant drugs and their controlled release property

Abstract

Keywords

ASJC Scopus subject areas

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