TY - JOUR
T1 - Morphology and development in Aspergillus nidulans
T2 - a complex puzzle.
AU - Harris, Steven D.
AU - Turner, Geoffrey
AU - Meyer, Vera
AU - Espeso, Eduardo A.
AU - Specht, Thomas
AU - Takeshita, Norio
AU - Helmstedt, Kerstin
N1 - Funding Information:
E.A.E is grateful to the Spanish Ministerio de Educación y Ciencia (D.G.I.C.Y.T) for support through Grant BFU2006-04185.
PY - 2009/3
Y1 - 2009/3
N2 - Like other filamentous fungi, Aspergillus nidulans forms a multitude of cell types that facilitate colonization and development. The molecular basis of cellular morphogenesis in A. nidulans is not well understood.Here, we summarize results obtained from detailed annotation of the A. nidulans genome sequence for genes with predicted roles in morphogenesis, with primary focus on polarized growth, calcium signaling, and development. We draw three broad conclusions from our results. First, the components of the signal transduction pathways and morphogenetic machinery as defined in the model yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe are largely conserved in A. nidulans. Second,A. nidulans possesses many additional genes implicated in morphogenesis that are not conserved in these yeasts. Third, the number of A. nidulans genes involved in morphogenesis is likely to be rather large;based on our annotation, we estimate that as many as 2000 A. nidulans genes encode proteins that may participate at some level in morphogenesis during vegetative growth and development.
AB - Like other filamentous fungi, Aspergillus nidulans forms a multitude of cell types that facilitate colonization and development. The molecular basis of cellular morphogenesis in A. nidulans is not well understood.Here, we summarize results obtained from detailed annotation of the A. nidulans genome sequence for genes with predicted roles in morphogenesis, with primary focus on polarized growth, calcium signaling, and development. We draw three broad conclusions from our results. First, the components of the signal transduction pathways and morphogenetic machinery as defined in the model yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe are largely conserved in A. nidulans. Second,A. nidulans possesses many additional genes implicated in morphogenesis that are not conserved in these yeasts. Third, the number of A. nidulans genes involved in morphogenesis is likely to be rather large;based on our annotation, we estimate that as many as 2000 A. nidulans genes encode proteins that may participate at some level in morphogenesis during vegetative growth and development.
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U2 - 10.1016/j.fgb.2008.07.023
DO - 10.1016/j.fgb.2008.07.023
M3 - Article
C2 - 19610202
AN - SCOPUS:67650617263
SN - 1087-1845
VL - 46 Suppl 1
SP - S82-S92
JO - Fungal Genetics and Biology
JF - Fungal Genetics and Biology
ER -