TY - JOUR
T1 - Motor and absorptive function of the canine intestine following serosal patching
T2 - The effects of a lateral enterotomy on small intestinal myoelectrical activity
AU - Thompson, J. S.
AU - Quigley, E. M.M.
N1 - Funding Information:
This work was supported in part by the Veterans Administration Merit Review Program. Address correspondence to Jon S. Thompson, MD, University of Nebraska Medical Center, Department of Surgery, 600 South 42nd Street, Omaha, NE 68198.
PY - 1991
Y1 - 1991
N2 - We studied the effects of serosal patching of a 4 × 15-cm, full-thickness, jejunal defect on absorptive function and fasting and postprandial myoelectrical activity in 5 patched and 5 control animals over a 3-month period. While fat and D-xylose absorption were similar in both groups, serum albumin was significantly depressed (2.96 ± 0.24 g/dL preop vs 2.29 ± 0.23 g/dL postop, p > 05) andstool moisture content was elevated following patching (54 ± 4% vs 67 ± 9% p > 05). Neither the generation of the various phases of the interdigestive myoelectrical complex (IDMEC), the development of postprandial myoelectrical activity, or colonic myoelectrical patterns were impaired in the patched animals. The normal gradients of slow wave frequency, phase III propagation velocity, and onset of the fed pattern were similar in control and patched animals. However, jejunal slow wave frequency (cpm, control vs patch: 18.6 ± 0.6 vs 19.5 ± 0.6, p > 05) and IDMEC frequency (0.36 ± 0.25 vs 0.56 ± 0.32, p > 05) were greater and the IDMEC period shorter (109.6 ± 27.8 vs 88 ± 35.7, p > 05) in the patch animals. In vitro studies demonstrated similar absorptive function in intact mucosa and neomucosa. We conclude that the technique of serosal patching is associated with impaired absorption in vivo. While this may be related, in part, to the minor motility changes observed, other factors such as hormonal changes may also be important
AB - We studied the effects of serosal patching of a 4 × 15-cm, full-thickness, jejunal defect on absorptive function and fasting and postprandial myoelectrical activity in 5 patched and 5 control animals over a 3-month period. While fat and D-xylose absorption were similar in both groups, serum albumin was significantly depressed (2.96 ± 0.24 g/dL preop vs 2.29 ± 0.23 g/dL postop, p > 05) andstool moisture content was elevated following patching (54 ± 4% vs 67 ± 9% p > 05). Neither the generation of the various phases of the interdigestive myoelectrical complex (IDMEC), the development of postprandial myoelectrical activity, or colonic myoelectrical patterns were impaired in the patched animals. The normal gradients of slow wave frequency, phase III propagation velocity, and onset of the fed pattern were similar in control and patched animals. However, jejunal slow wave frequency (cpm, control vs patch: 18.6 ± 0.6 vs 19.5 ± 0.6, p > 05) and IDMEC frequency (0.36 ± 0.25 vs 0.56 ± 0.32, p > 05) were greater and the IDMEC period shorter (109.6 ± 27.8 vs 88 ± 35.7, p > 05) in the patch animals. In vitro studies demonstrated similar absorptive function in intact mucosa and neomucosa. We conclude that the technique of serosal patching is associated with impaired absorption in vivo. While this may be related, in part, to the minor motility changes observed, other factors such as hormonal changes may also be important
KW - Intestinal absorption
KW - Intestinal motility
KW - Serosal patch
KW - Short bowel syndrome
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U2 - 10.3109/08941939109140780
DO - 10.3109/08941939109140780
M3 - Article
C2 - 2069930
AN - SCOPUS:0025810471
SN - 0894-1939
VL - 4
SP - 203
EP - 215
JO - Journal of Investigative Surgery
JF - Journal of Investigative Surgery
IS - 2
ER -