Mouse model of post-arthroplasty Staphylococcus epidermidis joint infection

Tyler D. Scherr, Kevin E. Lindgren, Carolyn R. Schaeffer, Mark L. Hanke, Curtis W. Hartman, Tammy Kielian

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Scopus citations

Abstract

Animal models are invaluable tools for translational research, allowing investigators to recapitulate observed clinical scenarios within the laboratory that share attributes with human disease. Here, we describe a mouse model of post-arthroplasty Staphylococcus epidermidis joint infection which mimics human disease and may be utilized to explore the complex series of events during staphylococcal implant-associated infections by identifying key immunological, bacterial, and/or therapeutic mechanisms relevant to these persistent infections.

Original languageEnglish (US)
Title of host publicationStaphylococcus Epidermidis
Subtitle of host publicationMethods and Protocols
PublisherHumana Press Inc.
Pages173-181
Number of pages9
ISBN (Print)9781627037358
DOIs
StatePublished - 2014

Publication series

NameMethods in Molecular Biology
Volume1106
ISSN (Print)1064-3745

Keywords

  • Biofilm
  • Implant-associated
  • Medical device
  • Osteomyelitis
  • Post-arthroplasty
  • Staphylococcus epidermidis

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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