Mouse model of post-arthroplasty Staphylococcus epidermidis joint infection

Tyler D. Scherr, Kevin E. Lindgren, Carolyn R. Schaeffer, Mark L. Hanke, Curtis W. Hartman, Tammy Kielian

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Scopus citations

Abstract

Animal models are invaluable tools for translational research, allowing investigators to recapitulate observed clinical scenarios within the laboratory that share attributes with human disease. Here, we describe a mouse model of post-arthroplasty Staphylococcus epidermidis joint infection which mimics human disease and may be utilized to explore the complex series of events during staphylococcal implant-associated infections by identifying key immunological, bacterial, and/or therapeutic mechanisms relevant to these persistent infections.

Original languageEnglish (US)
Title of host publicationStaphylococcus Epidermidis
Subtitle of host publicationMethods and Protocols
PublisherHumana Press Inc.
Pages173-181
Number of pages9
ISBN (Print)9781627037358
DOIs
StatePublished - 2014

Publication series

NameMethods in Molecular Biology
Volume1106
ISSN (Print)1064-3745

Keywords

  • Biofilm
  • Implant-associated
  • Medical device
  • Osteomyelitis
  • Post-arthroplasty
  • Staphylococcus epidermidis

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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