Mouse models of uveal melanoma: Strengths, weaknesses, and future directions

Jackson R. Richards, Jae Hyuk Yoo, Donghan Shin, Shannon J. Odelberg

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

Uveal melanoma is the most common primary malignancy of the eye, and a number of discoveries in the last decade have led to a more thorough molecular characterization of this cancer. However, the prognosis remains dismal for patients with metastases, and there is an urgent need to identify treatments that are effective for this stage of disease. Animal models are important tools for preclinical studies of uveal melanoma. A variety of models exist, and they have specific advantages, disadvantages, and applications. In this review article, these differences are explored in detail, and ideas for new models that might overcome current challenges are proposed.

Original languageEnglish (US)
Pages (from-to)264-278
Number of pages15
JournalPigment Cell and Melanoma Research
Volume33
Issue number2
DOIs
StatePublished - Mar 1 2020
Externally publishedYes

Keywords

  • melanoma
  • mouse
  • transgenic mouse
  • uveal
  • xenograft

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Oncology
  • Dermatology

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