Moxalactam myoclonus, seizures, and encephalopathy

I. Cho; J. M. Bertoni; L. Hopkins

doi:10.1177/106002808602000310

Moxalactam myoclonus, seizures, and encephalopathy

I. Cho, J. M. Bertoni, L. Hopkins

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Severe myoclonus, generalized seizures, and marked stupor occurred in a 39-year-old woman with chronic renal insufficiency after one week of moxalactam 2 g iv q8h. Moxalactam serum levels far exceeded the recommended therapeutic range. The drug half-life was 17 hours (normal 1.9). Excessively high levels of moxalactam, which penetrates the blood-brain-barrier relatively easily, may provoke seizures and encephalopathy.

Original language	English (US)
Pages (from-to)	223-224
Number of pages	2
Journal	Drug Intelligence and Clinical Pharmacy
Volume	20
Issue number	3
DOIs	https://doi.org/10.1177/106002808602000310
State	Published - 1986
Externally published	Yes

ASJC Scopus subject areas

Pharmacology, Toxicology and Pharmaceutics(all)
Pharmacology (medical)

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abstract = "Severe myoclonus, generalized seizures, and marked stupor occurred in a 39-year-old woman with chronic renal insufficiency after one week of moxalactam 2 g iv q8h. Moxalactam serum levels far exceeded the recommended therapeutic range. The drug half-life was 17 hours (normal 1.9). Excessively high levels of moxalactam, which penetrates the blood-brain-barrier relatively easily, may provoke seizures and encephalopathy.",

author = "I. Cho and Bertoni, {J. M.} and L. Hopkins",

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AU - Bertoni, J. M.

AU - Hopkins, L.

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AB - Severe myoclonus, generalized seizures, and marked stupor occurred in a 39-year-old woman with chronic renal insufficiency after one week of moxalactam 2 g iv q8h. Moxalactam serum levels far exceeded the recommended therapeutic range. The drug half-life was 17 hours (normal 1.9). Excessively high levels of moxalactam, which penetrates the blood-brain-barrier relatively easily, may provoke seizures and encephalopathy.

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Moxalactam myoclonus, seizures, and encephalopathy

Abstract

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