MR diffusion imaging of cerebral infarction in humans

D. Chien, K. K. Kwong, D. R. Gress, F. S. Buonanno, R. B. Buxton, B. R. Rosen, M. Fisher, C. H. Sotak

Research output: Contribution to journalArticlepeer-review

262 Scopus citations


Purpose: MR diffusion imaging was performed to investigate changes in water diffusion in patients with cerebral infarction. Methods: Diffusion maps of the apparent diffusion coefficient (ADC) were created to show local water mobility in the brain tissue in 15 patients. These ADC maps were compared with conventional T2-weighted images. Results: Distinct subregions with different water diffusions were detected, even when the infarcted area appeared homogeneous on a T2-weighted image. The results also show that stroke lesions of the same age can have very different water diffusions. A trend towards an increasing diffusion coefficient in a lesion during the first several days following an acute event was observed in a group of patients imaged at multiple timepoints. Conclusion: The measurement of diffusion coefficients in vivo now offers an opportunity for greater understanding of the biophysical changes that occur during the evolution of infarction in humans.

Original languageEnglish (US)
Pages (from-to)1097-1106
Number of pages10
JournalAmerican Journal of Neuroradiology
Issue number4
StatePublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology


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