Purpose: Nearly a quarter of neurofibromatosis type 1 (NF 1)- associated diencephalic low-grade tumors are refractory to chemotherapy. Addition of alternative treatment options with laser interstitial thermal therapy will have a positive impact on the outcome of these patients. Methods: We report on two illustrated cases of pediatric NF1- associated, chemoresistant, WHO grade 1 pilocytic astrocytomas treated with laser interstitial thermal therapy (LITT). Results: Both tumors responded favorably to LITT. Conclusion: LITT should be considered as a treatment option for chemoresistant deep-seated NF1-associated low-grade gliomas.
- Deep-seated gliomas
- Laser interstitial thermal therapy
- Neurofibromatosis type 1
- Thalamic tumors
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Clinical Neurology