@inproceedings{351bbf59ce6a4c24afbaba945da49cb9,
title = "MUC16 as a potential target for the surgical detection of pancreatic cancer",
abstract = "Pancreatic cancer is the third leading cause of cancer-related deaths in the United States. Up to 20% of patients are candidates for resection, which is currently the only potentially curative treatment option. However, pancreatic cancer patients have high rates of recurrence after resection due in part to cells left behind at the surgical margin. Fluorescence guided surgery (FGS) has emerged as a method to improve surgical resection. For pancreatic cancer patients eligible for surgical resection, intraoperative imaging would serve two purposes. For patients with resectable disease, image-guidance could help delineate tumor ti{\ss}ue to achieve complete resection. Of critical value, fluorescence guided surgery (FGS) could be used to identify locally metastatic disease, which could spare the patient from major, unnece{\ss}ary surgery and move directly to other treatments. Recent studies demonstrated that MUC16 is overexpre{\ss}ed in 60-80% of pancreatic cancers, but this biomarker has not yet been explored for FGS of pancreatic cancer. Herein, we describe the validation and development of a near infrared fluorescence antibody that recognizes MUC16 for surgical imaging.",
keywords = "Fluorescence Guided Surgery, IRDye800, MUC16, Near Infrared Fluorescence, Optical Imaging, Pancreatic Cancer, Surgical Resection",
author = "Olson, {Madeline T.} and Wojtynek, {Nicholas E.} and Caffrey, {Thomas C.} and Prakash Radhakrishnan and Ly, {Quan P.} and Talmon, {Geoffrey A.} and Hollingsworth, {Michael A.} and Mohs, {Aaron M.}",
note = "Publisher Copyright: {\textcopyright} COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.; Molecular-Guided Surgery: Molecules, Devices, and Applications VI 2020 ; Conference date: 01-02-2020 Through 02-02-2020",
year = "2020",
doi = "10.1117/12.2550648",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Sylvain Gioux and Gibbs, {Summer L.} and Pogue, {Brian W.}",
booktitle = "Molecular-Guided Surgery",
}