Abstract

Pancreatic cancer is the third leading cause of cancer-related deaths in the United States. Up to 20% of patients are candidates for resection, which is currently the only potentially curative treatment option. However, pancreatic cancer patients have high rates of recurrence after resection due in part to cells left behind at the surgical margin. Fluorescence guided surgery (FGS) has emerged as a method to improve surgical resection. For pancreatic cancer patients eligible for surgical resection, intraoperative imaging would serve two purposes. For patients with resectable disease, image-guidance could help delineate tumor tißue to achieve complete resection. Of critical value, fluorescence guided surgery (FGS) could be used to identify locally metastatic disease, which could spare the patient from major, unneceßary surgery and move directly to other treatments. Recent studies demonstrated that MUC16 is overexpreßed in 60-80% of pancreatic cancers, but this biomarker has not yet been explored for FGS of pancreatic cancer. Herein, we describe the validation and development of a near infrared fluorescence antibody that recognizes MUC16 for surgical imaging.

Original languageEnglish (US)
Title of host publicationMolecular-Guided Surgery
Subtitle of host publicationMolecules, Devices, and Applications VI
EditorsSylvain Gioux, Summer L. Gibbs, Brian W. Pogue
PublisherSPIE
ISBN (Electronic)9781510632073
DOIs
StatePublished - Jan 1 2020
EventMolecular-Guided Surgery: Molecules, Devices, and Applications VI 2020 - San Francisco, United States
Duration: Feb 1 2020Feb 2 2020

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume11222
ISSN (Print)1605-7422

Conference

ConferenceMolecular-Guided Surgery: Molecules, Devices, and Applications VI 2020
CountryUnited States
CitySan Francisco
Period2/1/202/2/20

Keywords

  • Fluorescence Guided Surgery
  • IRDye800
  • MUC16
  • Near Infrared Fluorescence
  • Optical Imaging
  • Pancreatic Cancer
  • Surgical Resection

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Olson, M. T., Wojtynek, N. E., Caffrey, T. C., Radhakrishnan, P., Ly, Q. P., Talmon, G. A., Hollingsworth, M. A., & Mohs, A. M. (2020). MUC16 as a potential target for the surgical detection of pancreatic cancer. In S. Gioux, S. L. Gibbs, & B. W. Pogue (Eds.), Molecular-Guided Surgery: Molecules, Devices, and Applications VI [112220M] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11222). SPIE. https://doi.org/10.1117/12.2550648