MUC4: A novel prognostic factor of oral squamous cell carcinoma

Tomofumi Hamada, Tsunenobu Wakamatsu, Mayumi Miyahara, Satoshi Nagata, Masahiro Nomura, Yoshiaki Kamikawa, Norishige Yamada, Surinder K. Batra, Suguru Yonezawa, Kazumasa Sugihara

Research output: Contribution to journalArticle

34 Scopus citations


MUC4 mucin is now known to be expressed in various normal and cancer tissues. We have previously reported that MUC4 expression is a novel prognostic factor in several malignant tumors; however, it has not been investigated in oral squamous cell carcinoma (OSCC). The aim of our study is to evaluate the prognostic significance of MUC4 expression in OSCC. We examined the expression profile of MUC4 in OSCC tissues from 150 patients using immunohistochemistry. Its prognostic significance in OSCC was statistically analyzed. MUC4 was expressed in 61 of the 150 patients with OSCC. MUC4 expression was significantly correlated with higher T classification (p = 0.0004), positive nodal metastasis (p = 0.049), advanced tumor stage (p = 0.002), diffuse invasion of cancer cells (p = 0.004) and patient's death (p = 0.004) in OSCC. Multivariate analysis showed that MUC4 expression (p = 0.011), tumor location (p = 0.032) and diffuse invasion (p = 0.009) were statistically significant risk factors. Backward stepwise multivariate analysis demonstrated MUC4 expression (p = 0.0015) and diffuse invasion (p = 0.018) to be statistically significant independent risk factors of poor survival in OSCC. The disease-free and overall survival of patients with MUC4 expression was significantly worse than those without MUC4 expression (p < 0.0001 and p = 0.0001). In addition, the MUC4 expression was a significant risk factor for local recurrence and subsequent nodal metastasis in OSCC (p = 0.017 and p = 0.0001). We first report MUC4 overexpression is an independent factor for poor prognosis of patients with OSCC; therefore, patients with OSCC showing positive MUC4 expression should be followed up carefully.

Original languageEnglish (US)
Pages (from-to)1768-1776
Number of pages9
JournalInternational Journal of Cancer
Issue number8
StatePublished - Apr 15 2012


  • MUC4
  • immunohistochemistry
  • mucin
  • oral cancer
  • prognosis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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