Mucin family of glycoproteins

R. B. Brown, M. A. Hollingsworth

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Mucins are large glycoproteins expressed by epithelial membranes and as components of the mucus secretions that cover epithelia in harsh environments - the air-water interface of the respiratory system, the acidic environment of the stomach, the complex environment of the intestinal tract, and secretory epithelial surfaces of specialized organs such as liver, pancreas, kidneys, gall bladder, salivary glands, lacrimal glands, and eye. Mucins are critical in maintaining homeostasis in environments that fluctuate in molecular composition - including pH, ionic concentration, oxygenation, and hydration. The molecular composition and higher-order structures of mucins offer specialized functions in the external environment, while relaying information about the environment to the cell via signal transduction through membrane-associated mucins.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Biological Chemistry
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages200-204
Number of pages5
ISBN (Electronic)9780123786319
ISBN (Print)9780123786302
DOIs
StatePublished - Feb 15 2013

Keywords

  • D-domain
  • Mucin
  • O-glycosylation
  • SEA domain
  • Tandem repeat

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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