Mucin family of glycoproteins

R. B. Brown; M. A. Hollingsworth

doi:10.1016/B978-0-12-378630-2.00670-8

Mucin family of glycoproteins

R. B. Brown, M. A. Hollingsworth

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Mucins are large glycoproteins expressed by epithelial membranes and as components of the mucus secretions that cover epithelia in harsh environments - the air-water interface of the respiratory system, the acidic environment of the stomach, the complex environment of the intestinal tract, and secretory epithelial surfaces of specialized organs such as liver, pancreas, kidneys, gall bladder, salivary glands, lacrimal glands, and eye. Mucins are critical in maintaining homeostasis in environments that fluctuate in molecular composition - including pH, ionic concentration, oxygenation, and hydration. The molecular composition and higher-order structures of mucins offer specialized functions in the external environment, while relaying information about the environment to the cell via signal transduction through membrane-associated mucins.

Original language	English (US)
Title of host publication	Encyclopedia of Biological Chemistry
Subtitle of host publication	Second Edition
Publisher	Elsevier Inc.
Pages	200-204
Number of pages	5
ISBN (Electronic)	9780123786319
ISBN (Print)	9780123786302
DOIs	https://doi.org/10.1016/B978-0-12-378630-2.00670-8
State	Published - Feb 15 2013

Keywords

D-domain
Mucin
O-glycosylation
SEA domain
Tandem repeat

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1016/B978-0-12-378630-2.00670-8

Fingerprint Dive into the research topics of 'Mucin family of glycoproteins'. Together they form a unique fingerprint.

Cite this

Brown, R. B., & Hollingsworth, M. A. (2013). Mucin family of glycoproteins. In Encyclopedia of Biological Chemistry: Second Edition (pp. 200-204). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-378630-2.00670-8

@inbook{0ca50b9f130449cab1f3cb420e137055,

title = "Mucin family of glycoproteins",

abstract = "Mucins are large glycoproteins expressed by epithelial membranes and as components of the mucus secretions that cover epithelia in harsh environments - the air-water interface of the respiratory system, the acidic environment of the stomach, the complex environment of the intestinal tract, and secretory epithelial surfaces of specialized organs such as liver, pancreas, kidneys, gall bladder, salivary glands, lacrimal glands, and eye. Mucins are critical in maintaining homeostasis in environments that fluctuate in molecular composition - including pH, ionic concentration, oxygenation, and hydration. The molecular composition and higher-order structures of mucins offer specialized functions in the external environment, while relaying information about the environment to the cell via signal transduction through membrane-associated mucins.",

keywords = "D-domain, Mucin, O-glycosylation, SEA domain, Tandem repeat",

author = "Brown, {R. B.} and Hollingsworth, {M. A.}",

year = "2013",

month = feb,

day = "15",

doi = "10.1016/B978-0-12-378630-2.00670-8",

language = "English (US)",

isbn = "9780123786302",

pages = "200--204",

booktitle = "Encyclopedia of Biological Chemistry",

publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Mucin family of glycoproteins

AU - Brown, R. B.

AU - Hollingsworth, M. A.

PY - 2013/2/15

Y1 - 2013/2/15

N2 - Mucins are large glycoproteins expressed by epithelial membranes and as components of the mucus secretions that cover epithelia in harsh environments - the air-water interface of the respiratory system, the acidic environment of the stomach, the complex environment of the intestinal tract, and secretory epithelial surfaces of specialized organs such as liver, pancreas, kidneys, gall bladder, salivary glands, lacrimal glands, and eye. Mucins are critical in maintaining homeostasis in environments that fluctuate in molecular composition - including pH, ionic concentration, oxygenation, and hydration. The molecular composition and higher-order structures of mucins offer specialized functions in the external environment, while relaying information about the environment to the cell via signal transduction through membrane-associated mucins.

AB - Mucins are large glycoproteins expressed by epithelial membranes and as components of the mucus secretions that cover epithelia in harsh environments - the air-water interface of the respiratory system, the acidic environment of the stomach, the complex environment of the intestinal tract, and secretory epithelial surfaces of specialized organs such as liver, pancreas, kidneys, gall bladder, salivary glands, lacrimal glands, and eye. Mucins are critical in maintaining homeostasis in environments that fluctuate in molecular composition - including pH, ionic concentration, oxygenation, and hydration. The molecular composition and higher-order structures of mucins offer specialized functions in the external environment, while relaying information about the environment to the cell via signal transduction through membrane-associated mucins.

KW - D-domain

KW - Mucin

KW - O-glycosylation

KW - SEA domain

KW - Tandem repeat

UR - http://www.scopus.com/inward/record.url?scp=85042761116&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85042761116&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-378630-2.00670-8

DO - 10.1016/B978-0-12-378630-2.00670-8

M3 - Chapter

AN - SCOPUS:85042761116

SN - 9780123786302

SP - 200

EP - 204

BT - Encyclopedia of Biological Chemistry

PB - Elsevier Inc.

ER -