TY - JOUR
T1 - Mucin-interacting proteins
T2 - From function to therapeutics
AU - Senapati, Shantibhusan
AU - Das, Srustidhar
AU - Batra, Surinder K.
N1 - Funding Information:
The authors on this work are supported by grants from the National Institutes of Health (CA78590, CA111294, CA133774 and CA131944) and Department of Defense (PC081409, BC074639 and BC083295). We thank Ms. Kristi L. Berger for editing the manuscript and Mrs. Utkalika Mohapatra for helping in making the illustration. We also sincerely thank the reviewers for their very constructive comments and corrections that have helped to improve this manuscript.
PY - 2010/4
Y1 - 2010/4
N2 - Mucins are high molecular weight glycoproteins that are involved in regulating diverse cellular activities both in normal and pathological conditions. Mucin activity and localization is mediated by several molecular mechanisms, including discrete interactions with other proteins. An understanding of the biochemistry behind the known interactions between mucins and other proteins, coupled with an appreciation of their pathophysiological significance, can lend insight into the development of novel therapeutic agents. Indeed, a recent study demonstrated that a cell permeable inhibitor, PMIP, that disrupts the MUC1-EGFR interaction, is effective in killing breast cancer cells in vitro and in tumor models.
AB - Mucins are high molecular weight glycoproteins that are involved in regulating diverse cellular activities both in normal and pathological conditions. Mucin activity and localization is mediated by several molecular mechanisms, including discrete interactions with other proteins. An understanding of the biochemistry behind the known interactions between mucins and other proteins, coupled with an appreciation of their pathophysiological significance, can lend insight into the development of novel therapeutic agents. Indeed, a recent study demonstrated that a cell permeable inhibitor, PMIP, that disrupts the MUC1-EGFR interaction, is effective in killing breast cancer cells in vitro and in tumor models.
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U2 - 10.1016/j.tibs.2009.10.003
DO - 10.1016/j.tibs.2009.10.003
M3 - Review article
C2 - 19913432
AN - SCOPUS:77951019810
SN - 0968-0004
VL - 35
SP - 236
EP - 245
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
IS - 4
ER -