Mucin-interacting proteins: From function to therapeutics

Shantibhusan Senapati, Srustidhar Das, Surinder K. Batra

Research output: Contribution to journalReview articlepeer-review

130 Scopus citations

Abstract

Mucins are high molecular weight glycoproteins that are involved in regulating diverse cellular activities both in normal and pathological conditions. Mucin activity and localization is mediated by several molecular mechanisms, including discrete interactions with other proteins. An understanding of the biochemistry behind the known interactions between mucins and other proteins, coupled with an appreciation of their pathophysiological significance, can lend insight into the development of novel therapeutic agents. Indeed, a recent study demonstrated that a cell permeable inhibitor, PMIP, that disrupts the MUC1-EGFR interaction, is effective in killing breast cancer cells in vitro and in tumor models.

Original languageEnglish (US)
Pages (from-to)236-245
Number of pages10
JournalTrends in Biochemical Sciences
Volume35
Issue number4
DOIs
StatePublished - Apr 2010

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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