TY - JOUR
T1 - Mucins in cancer
T2 - Protection and control of the cell surface
AU - Hollingsworth, Michael A.
AU - Swanson, Benjamin J.
N1 - Funding Information:
Research in M.A.H.'s laboratory is supported by grants from the National Cancer Institute (NCI) of the National Institutes of Health. B.J.S. is supported by an NCI training grant and by the University of Nebraska Medical Center. The authors thank the reviewers and the following individuals for helpful suggestions and discussions: J. Anderson, S. Batra, T. Caffrey, J. Gum, A. Harris, A. Rizzino, X. Shen, P. Singh, J. Tremayne, H. Tsutsumeida, C. Yi, G. Suryanarayanan and Y. Wen. We acknowledge that this field of research is built upon the efforts of many and apologize to those authors not cited here because of the need for brevity.
PY - 2004/1
Y1 - 2004/1
N2 - Mucins - large extracellular proteins that are heavily glycosylated with complex oligosaccharides - establish a selective molecular barrier at the epithelial surface and engage in morphogenetic signal transduction. Alterations in mucin expression or glycosylation accompany the development of cancer and influence cellular growth, differentiation, transformation, adhesion, invasion and immune surveillance. Mucins are used as diagnostic markers in cancer, and are under investigation as therapeutic targets for cancer.
AB - Mucins - large extracellular proteins that are heavily glycosylated with complex oligosaccharides - establish a selective molecular barrier at the epithelial surface and engage in morphogenetic signal transduction. Alterations in mucin expression or glycosylation accompany the development of cancer and influence cellular growth, differentiation, transformation, adhesion, invasion and immune surveillance. Mucins are used as diagnostic markers in cancer, and are under investigation as therapeutic targets for cancer.
UR - http://www.scopus.com/inward/record.url?scp=0347123435&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0347123435&partnerID=8YFLogxK
U2 - 10.1038/nrc1251
DO - 10.1038/nrc1251
M3 - Review article
C2 - 14681689
AN - SCOPUS:0347123435
SN - 1474-175X
VL - 4
SP - 45
EP - 60
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
IS - 1
ER -