TY - JOUR
T1 - Mucins in the pathogenesis of breast cancer
T2 - Implications in diagnosis, prognosis and therapy
AU - Mukhopadhyay, Partha
AU - Chakraborty, Subhankar
AU - Ponnusamy, Moorthy P.
AU - Lakshmanan, Imayavaramban
AU - Jain, Maneesh
AU - Batra, Surinder K.
N1 - Funding Information:
The authors on this work are supported by grants from the Department of Defense ( BC074639 , BC083295 , and BC09742 ), the National Institutes of Health ( RO1 CA78590 , EDRN UO1 CA111294 , RO1 CA133774 , RO1 CA131944 , P50 CA127297 and RO3 CA139285 ) and the Susan Komen Foundation ( KG070826 ). We also thank Drs. S. Kaur, V.S Gnanapragassam, S. Das, and also D. Haridas for critical reading and suggestions on this review article.
PY - 2011/4
Y1 - 2011/4
N2 - Mucins are high molecular weight, multifunctional glycoproteins comprised of two structural classes-the large transmembrane mucins and the gel-forming or secreted mucins. The primary function of mucins is to protect and lubricate the luminal surfaces of epithelium-lined ducts in the human body. Recent studies have identified a differential expression of both membrane bound (MUC1, MUC4 and MUC16) and secreted mucins (MUC2, MUC5AC, MUC5B and MUC6) in breast cancer tissues when compared with the non-neoplastic breast tissues. Functional studies have also uncovered many unique roles of mucins during the progression of breast cancer, which include modulation in proliferative, invasive and metastatic potential of tumor cells. Mucins function through many unique domains that can form complex association with various signaling molecules including growth factor receptors and intercellular adhesion molecules. While there is growing information about mucins in various malignancies including breast cancer, no focused review is there on the expression and functional roles of mucins in breast cancer. In this present review, we have discussed the differential expression and functional roles of mucins in breast cancer. The potential of mucins as diagnostic and prognostic markers and as therapeutic targets in breast cancer have also been discussed.
AB - Mucins are high molecular weight, multifunctional glycoproteins comprised of two structural classes-the large transmembrane mucins and the gel-forming or secreted mucins. The primary function of mucins is to protect and lubricate the luminal surfaces of epithelium-lined ducts in the human body. Recent studies have identified a differential expression of both membrane bound (MUC1, MUC4 and MUC16) and secreted mucins (MUC2, MUC5AC, MUC5B and MUC6) in breast cancer tissues when compared with the non-neoplastic breast tissues. Functional studies have also uncovered many unique roles of mucins during the progression of breast cancer, which include modulation in proliferative, invasive and metastatic potential of tumor cells. Mucins function through many unique domains that can form complex association with various signaling molecules including growth factor receptors and intercellular adhesion molecules. While there is growing information about mucins in various malignancies including breast cancer, no focused review is there on the expression and functional roles of mucins in breast cancer. In this present review, we have discussed the differential expression and functional roles of mucins in breast cancer. The potential of mucins as diagnostic and prognostic markers and as therapeutic targets in breast cancer have also been discussed.
KW - Apoptosis
KW - Breast cancer
KW - Cancer
KW - Cell survival
KW - MUC1 (DF3)
KW - MUC16 (CA125)
KW - MUC4
KW - Mucins
KW - Polymorphic epithelial mucins
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U2 - 10.1016/j.bbcan.2011.01.001
DO - 10.1016/j.bbcan.2011.01.001
M3 - Review article
C2 - 21277939
AN - SCOPUS:79951583142
SN - 0304-419X
VL - 1815
SP - 224
EP - 240
JO - Biochimica et Biophysica Acta - Reviews on Cancer
JF - Biochimica et Biophysica Acta - Reviews on Cancer
IS - 2
ER -