Mucosal HIV-1 transmission and prevention strategies in BLT humanized mice

Paul W. Denton, J. Victor Garcia

Research output: Contribution to journalReview articlepeer-review

48 Scopus citations

Abstract

Clinical trials testing microbicides and related biomedical interventions to block HIV transmissions have produced contradictory results and to date it is unclear why. Further elucidation of the molecular basis of mucosal HIV transmission and extensive pharmacokinetic and pharmacodynamic analyses are essential to implementing effective prevention strategies. Animal models are of critical importance to this effort and bone marrow-liver-thymus (BLT) humanized mice have recently emerged as a powerful small animal research platform for . in vivo efficacy evaluation of mucosal and parenteral HIV-1 prevention interventions. The availability of this validated system for the pre-clinical evaluation of HIV-1 prevention approaches will accelerate the implementation of the best candidate interventions into clinical trials.

Original languageEnglish (US)
Pages (from-to)268-274
Number of pages7
JournalTrends in Microbiology
Volume20
Issue number6
DOIs
StatePublished - Jun 2012
Externally publishedYes

Keywords

  • BLT
  • Efficacy evaluation
  • HIV-1 prevention
  • Humanized mice
  • Microbicides
  • PrEP

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Virology

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