Multi-layer coated nanorobot end-effector for efficient drug delivery

Jing Yu, Yongliang Yang, Kristina Seiffert-Sinha, Ilsoon Lee, Ning Xi, Animesh A. Sinha, Ruiguo Yang, Bo Song, Liangliang Chen, Zhiyong Sun

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A multi-layer coating enabled drug delivery method has been developed here to augment AFM based nanorobot technology. Being developed for over a decade, the AFM based nanorobot has been established as a key concept of nanorobotics, and has been applied in nanomaterial and biomedical related research. In these AFM based nanorobots, however, the AFM tip was mainly used as a mechanical end-effector to execute pushing and cutting in previous development. With its strong application potential in drug discovery and cell biology, AFM based nanorobots carrying functionalized end-effector are in a strong demand. Previous functionalization of AFM tip was aimed for single molecular interaction measurement. It cannot meet the high volume drug loading for localized drug delivery. Here, we developed a multi-layer coating method to load a large amount of protein on AFM tip for long-time release (∼ 40 hours). Combined with the AFM based nanorobot previously developed in our lab, this technology would enable scientists to study mechanical cellular response to protein stimulations.

Original languageEnglish (US)
Title of host publication16th International Conference on Nanotechnology - IEEE NANO 2016
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages511-514
Number of pages4
ISBN (Electronic)9781509039142
DOIs
StatePublished - Nov 21 2016
Event16th IEEE International Conference on Nanotechnology - IEEE NANO 2016 - Sendai, Japan
Duration: Aug 22 2016Aug 25 2016

Publication series

Name16th International Conference on Nanotechnology - IEEE NANO 2016

Other

Other16th IEEE International Conference on Nanotechnology - IEEE NANO 2016
CountryJapan
CitySendai
Period8/22/168/25/16

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

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  • Cite this

    Yu, J., Yang, Y., Seiffert-Sinha, K., Lee, I., Xi, N., Sinha, A. A., Yang, R., Song, B., Chen, L., & Sun, Z. (2016). Multi-layer coated nanorobot end-effector for efficient drug delivery. In 16th International Conference on Nanotechnology - IEEE NANO 2016 (pp. 511-514). [7751526] (16th International Conference on Nanotechnology - IEEE NANO 2016). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NANO.2016.7751526