TY - GEN
T1 - Multi-layer coated nanorobot end-effector for efficient drug delivery
AU - Yu, Jing
AU - Yang, Yongliang
AU - Seiffert-Sinha, Kristina
AU - Lee, Ilsoon
AU - Xi, Ning
AU - Sinha, Animesh A.
AU - Yang, Ruiguo
AU - Song, Bo
AU - Chen, Liangliang
AU - Sun, Zhiyong
PY - 2016/11/21
Y1 - 2016/11/21
N2 - A multi-layer coating enabled drug delivery method has been developed here to augment AFM based nanorobot technology. Being developed for over a decade, the AFM based nanorobot has been established as a key concept of nanorobotics, and has been applied in nanomaterial and biomedical related research. In these AFM based nanorobots, however, the AFM tip was mainly used as a mechanical end-effector to execute pushing and cutting in previous development. With its strong application potential in drug discovery and cell biology, AFM based nanorobots carrying functionalized end-effector are in a strong demand. Previous functionalization of AFM tip was aimed for single molecular interaction measurement. It cannot meet the high volume drug loading for localized drug delivery. Here, we developed a multi-layer coating method to load a large amount of protein on AFM tip for long-time release (∼ 40 hours). Combined with the AFM based nanorobot previously developed in our lab, this technology would enable scientists to study mechanical cellular response to protein stimulations.
AB - A multi-layer coating enabled drug delivery method has been developed here to augment AFM based nanorobot technology. Being developed for over a decade, the AFM based nanorobot has been established as a key concept of nanorobotics, and has been applied in nanomaterial and biomedical related research. In these AFM based nanorobots, however, the AFM tip was mainly used as a mechanical end-effector to execute pushing and cutting in previous development. With its strong application potential in drug discovery and cell biology, AFM based nanorobots carrying functionalized end-effector are in a strong demand. Previous functionalization of AFM tip was aimed for single molecular interaction measurement. It cannot meet the high volume drug loading for localized drug delivery. Here, we developed a multi-layer coating method to load a large amount of protein on AFM tip for long-time release (∼ 40 hours). Combined with the AFM based nanorobot previously developed in our lab, this technology would enable scientists to study mechanical cellular response to protein stimulations.
UR - http://www.scopus.com/inward/record.url?scp=85006844249&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85006844249&partnerID=8YFLogxK
U2 - 10.1109/NANO.2016.7751526
DO - 10.1109/NANO.2016.7751526
M3 - Conference contribution
AN - SCOPUS:85006844249
T3 - 16th International Conference on Nanotechnology - IEEE NANO 2016
SP - 511
EP - 514
BT - 16th International Conference on Nanotechnology - IEEE NANO 2016
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 16th IEEE International Conference on Nanotechnology - IEEE NANO 2016
Y2 - 22 August 2016 through 25 August 2016
ER -