Multi-layer coated nanorobot end-effector for efficient drug delivery

Jing Yu; Yongliang Yang; Kristina Seiffert-Sinha; Ilsoon Lee; Ning Xi; Animesh A. Sinha; Ruiguo Yang; Bo Song; Liangliang Chen; Zhiyong Sun

doi:10.1109/NANO.2016.7751526

Multi-layer coated nanorobot end-effector for efficient drug delivery

Jing Yu, Yongliang Yang, Kristina Seiffert-Sinha, Ilsoon Lee, Ning Xi, Animesh A. Sinha, Ruiguo Yang, Bo Song, Liangliang Chen, Zhiyong Sun

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

A multi-layer coating enabled drug delivery method has been developed here to augment AFM based nanorobot technology. Being developed for over a decade, the AFM based nanorobot has been established as a key concept of nanorobotics, and has been applied in nanomaterial and biomedical related research. In these AFM based nanorobots, however, the AFM tip was mainly used as a mechanical end-effector to execute pushing and cutting in previous development. With its strong application potential in drug discovery and cell biology, AFM based nanorobots carrying functionalized end-effector are in a strong demand. Previous functionalization of AFM tip was aimed for single molecular interaction measurement. It cannot meet the high volume drug loading for localized drug delivery. Here, we developed a multi-layer coating method to load a large amount of protein on AFM tip for long-time release (∼ 40 hours). Combined with the AFM based nanorobot previously developed in our lab, this technology would enable scientists to study mechanical cellular response to protein stimulations.

Original language	English (US)
Title of host publication	16th International Conference on Nanotechnology - IEEE NANO 2016
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	511-514
Number of pages	4
ISBN (Electronic)	9781509039142
DOIs	https://doi.org/10.1109/NANO.2016.7751526
State	Published - Nov 21 2016
Externally published	Yes
Event	16th IEEE International Conference on Nanotechnology - IEEE NANO 2016 - Sendai, Japan Duration: Aug 22 2016 → Aug 25 2016

Publication series

Name	16th International Conference on Nanotechnology - IEEE NANO 2016

Other

Other	16th IEEE International Conference on Nanotechnology - IEEE NANO 2016
Country	Japan
City	Sendai
Period	8/22/16 → 8/25/16

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics

Access to Document

10.1109/NANO.2016.7751526

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Cite this

Yu, J., Yang, Y., Seiffert-Sinha, K., Lee, I., Xi, N., Sinha, A. A., Yang, R., Song, B., Chen, L., & Sun, Z. (2016). Multi-layer coated nanorobot end-effector for efficient drug delivery. In 16th International Conference on Nanotechnology - IEEE NANO 2016 (pp. 511-514). [7751526] (16th International Conference on Nanotechnology - IEEE NANO 2016). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NANO.2016.7751526

Multi-layer coated nanorobot end-effector for efficient drug delivery. / Yu, Jing; Yang, Yongliang; Seiffert-Sinha, Kristina; Lee, Ilsoon; Xi, Ning; Sinha, Animesh A.; Yang, Ruiguo; Song, Bo; Chen, Liangliang; Sun, Zhiyong.

16th International Conference on Nanotechnology - IEEE NANO 2016. Institute of Electrical and Electronics Engineers Inc., 2016. p. 511-514 7751526 (16th International Conference on Nanotechnology - IEEE NANO 2016).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Yu, J, Yang, Y, Seiffert-Sinha, K, Lee, I, Xi, N, Sinha, AA, Yang, R, Song, B, Chen, L & Sun, Z 2016, Multi-layer coated nanorobot end-effector for efficient drug delivery. in 16th International Conference on Nanotechnology - IEEE NANO 2016., 7751526, 16th International Conference on Nanotechnology - IEEE NANO 2016, Institute of Electrical and Electronics Engineers Inc., pp. 511-514, 16th IEEE International Conference on Nanotechnology - IEEE NANO 2016, Sendai, Japan, 8/22/16. https://doi.org/10.1109/NANO.2016.7751526

Yu J, Yang Y, Seiffert-Sinha K, Lee I, Xi N, Sinha AA et al. Multi-layer coated nanorobot end-effector for efficient drug delivery. In 16th International Conference on Nanotechnology - IEEE NANO 2016. Institute of Electrical and Electronics Engineers Inc. 2016. p. 511-514. 7751526. (16th International Conference on Nanotechnology - IEEE NANO 2016). https://doi.org/10.1109/NANO.2016.7751526

Yu, Jing ; Yang, Yongliang ; Seiffert-Sinha, Kristina ; Lee, Ilsoon ; Xi, Ning ; Sinha, Animesh A. ; Yang, Ruiguo ; Song, Bo ; Chen, Liangliang ; Sun, Zhiyong. / Multi-layer coated nanorobot end-effector for efficient drug delivery. 16th International Conference on Nanotechnology - IEEE NANO 2016. Institute of Electrical and Electronics Engineers Inc., 2016. pp. 511-514 (16th International Conference on Nanotechnology - IEEE NANO 2016).

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