Multicentre proton magnetic resonance spectroscopy imaging of primary progressive multiple sclerosis

Ponnada A. Narayana, Jerry S. Wolinsky, Sajja B. Rao, Renjie He, Meghana Mehta, William Books, Corey Ford, Todd Richards, James Bowen, J. William Lindsey, Yvan Boulanger, Pierre Duquette, Douglas L. Arnold

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


Multicentre baseline proton magnetic resonance spectroscopic data on primary progressive multiple sclerosis (PPMS) patients are acquired and analysed, using automatic analysis software. The metabolite ratios did not differ from centre to centre. The average N-acetylaspartate/creatine (NAA/Cr) ratio in PPMS was significantly lower compared to normal controls. No significant differences were observed in this ratio between lesion-containing regions (LCR) and normal-appearing tissues (NAT). Strong lipid resonances, even in the absence of lesions, are observed in the both grey and white matter in these patients. These observations suggest extensive diffuse and/or microscopic pathology in PPMS. No significant correlation between any of the metabolite ratios and the Extended Disability Scale Score (EDSS) or with other MR measures such as lesion burden and enhancement volumes is observed.

Original languageEnglish (US)
Pages (from-to)S73-S78
JournalMultiple Sclerosis
Issue numberSUPPL. 1
StatePublished - Jun 2004
Externally publishedYes


  • MRI
  • N-acetylaspartate
  • Primary progressive multiple sclerosis
  • Proton spectroscopic imaging

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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