TY - JOUR
T1 - Multimodal imaging nanoparticles derived from hyaluronic acid for integrated preoperative and intraoperative cancer imaging
AU - Payne, William M.
AU - Hill, Tanner K.
AU - Svechkarev, Denis
AU - Holmes, Megan B.
AU - Sajja, Balasrinivasa R.
AU - Mohs, Aaron M.
N1 - Funding Information:
This work was funded in part by National Institutes of Health Grants R01 EB019449, P20 GM103480, and P30 CA036727 and Nebraska Department of Health and Human Services Grant LB506 2017-41. The authors thank Melissa L. Mellon, Ahmad Tanwir, and Lirong Xu for technical assistance. They thank Dr. Michael D. Boska for his contributions to experimental design, MR processing, and manuscript editing.
Publisher Copyright:
© 2017 William M. Payne et al.
PY - 2017/9/11
Y1 - 2017/9/11
N2 - Surgical resection remains themost promising treatment strategy for many types of cancer. Residualmalignant tissue after surgery, a consequence in part due to positivemargins, contributes to highmortality and disease recurrence. In this study,multimodal contrast agents for integrated preoperativemagnetic resonance imaging (MRI) and intraoperative fluorescence image-guided surgery (FIGS) are developed. Self-assembled multimodal imaging nanoparticles (SAMINs) were developed as a mixed micelle formulation using amphiphilicHA polymers functionalized with either GdDTPA for T1 contrast-enhanced MRI or Cy7.5, a near infrared fluorophore. To evaluate the relationship betweenMRand fluorescence signal fromSAMINs, we employed simulated surgical phantoms that are routinely used to evaluate the depth at which near infrared (NIR) imaging agents can be detected by FIGS. Finally, imaging agent efficacy was evaluated in a human breast tumor xenograft model in nude mice, which demonstrated contrast in both fluorescence and magnetic resonance imaging.
AB - Surgical resection remains themost promising treatment strategy for many types of cancer. Residualmalignant tissue after surgery, a consequence in part due to positivemargins, contributes to highmortality and disease recurrence. In this study,multimodal contrast agents for integrated preoperativemagnetic resonance imaging (MRI) and intraoperative fluorescence image-guided surgery (FIGS) are developed. Self-assembled multimodal imaging nanoparticles (SAMINs) were developed as a mixed micelle formulation using amphiphilicHA polymers functionalized with either GdDTPA for T1 contrast-enhanced MRI or Cy7.5, a near infrared fluorophore. To evaluate the relationship betweenMRand fluorescence signal fromSAMINs, we employed simulated surgical phantoms that are routinely used to evaluate the depth at which near infrared (NIR) imaging agents can be detected by FIGS. Finally, imaging agent efficacy was evaluated in a human breast tumor xenograft model in nude mice, which demonstrated contrast in both fluorescence and magnetic resonance imaging.
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U2 - 10.1155/2017/9616791
DO - 10.1155/2017/9616791
M3 - Article
C2 - 29097944
AN - SCOPUS:85030695559
SN - 1555-4309
VL - 2017
JO - Contrast Media and Molecular Imaging
JF - Contrast Media and Molecular Imaging
M1 - 9616791
ER -