Surgical resection remains themost promising treatment strategy for many types of cancer. Residualmalignant tissue after surgery, a consequence in part due to positivemargins, contributes to highmortality and disease recurrence. In this study,multimodal contrast agents for integrated preoperativemagnetic resonance imaging (MRI) and intraoperative fluorescence image-guided surgery (FIGS) are developed. Self-assembled multimodal imaging nanoparticles (SAMINs) were developed as a mixed micelle formulation using amphiphilicHA polymers functionalized with either GdDTPA for T1 contrast-enhanced MRI or Cy7.5, a near infrared fluorophore. To evaluate the relationship betweenMRand fluorescence signal fromSAMINs, we employed simulated surgical phantoms that are routinely used to evaluate the depth at which near infrared (NIR) imaging agents can be detected by FIGS. Finally, imaging agent efficacy was evaluated in a human breast tumor xenograft model in nude mice, which demonstrated contrast in both fluorescence and magnetic resonance imaging.
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging