Multiple antimutagenesis mechanisms affect mutagenic activity and specificity of the base analog 6-N-hydroxylaminopurine in bacteria and yeast

Stanislav G. Kozmin, Roel M. Schaaper, Polina V. Shcherbakova, Vladimir N. Kulikov, Vladimir N. Noskov, Maria L. Guetsova, Vladimir V. Alenin, Igor B. Rogozin, Kira S. Makarova, Youri I. Pavlov

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Base analog 6-N-hydroxylaminopurine is a potent mutagen in variety of prokaryotic and eukaryotic organisms. In the review, we discuss recent results of the studies of HAP mutagenic activity, genetic control and specificity in bacteria and yeast with the emphasis to the mechanisms protecting living cells from mutagenic and toxic effects of this base analog.

Original languageEnglish (US)
Pages (from-to)41-50
Number of pages10
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume402
Issue number1-2
DOIs
StatePublished - Jun 18 1998

Keywords

  • 6-N-hydroxylaminopurine
  • Antimutagenesis
  • DNA replication fidelity
  • Mutagenic specificity
  • Nucleic acid base analog
  • Purine biosynthesis

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Health, Toxicology and Mutagenesis

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