TY - JOUR
T1 - Multiple forms of rat liver L-asparagine synthetase
AU - Markin, Rodney S.
AU - Schuster, Sheldon M.
PY - 1979/5/28
Y1 - 1979/5/28
N2 - Extraction of rat liver asparagine synthetase from rats maintained on normal protein containing diets yields activity in a region corresponding to a molecular weight of 57,000. Decreasing the amount of protein in the diets caused the asparagine synthetase activity to appear in two forms, one being in the 57,000 region and the other in the 113,000 region. If rat were fed a high protein diet, liver asparagine synthetase activity appeared only in the lower molecular weight area. Experiments with synthetic amino acid diets demonstrated that a dietary deficiency in asparagine would cause the appearance of high molecular weight (113,000) hepatic asparagine synthetase.
AB - Extraction of rat liver asparagine synthetase from rats maintained on normal protein containing diets yields activity in a region corresponding to a molecular weight of 57,000. Decreasing the amount of protein in the diets caused the asparagine synthetase activity to appear in two forms, one being in the 57,000 region and the other in the 113,000 region. If rat were fed a high protein diet, liver asparagine synthetase activity appeared only in the lower molecular weight area. Experiments with synthetic amino acid diets demonstrated that a dietary deficiency in asparagine would cause the appearance of high molecular weight (113,000) hepatic asparagine synthetase.
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U2 - 10.1016/0006-291X(79)92088-6
DO - 10.1016/0006-291X(79)92088-6
M3 - Article
C2 - 37836
AN - SCOPUS:0018803273
SN - 0006-291X
VL - 88
SP - 583
EP - 588
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -