Multiple Recurrent Paraganglioma in a Pediatric Patient with Germline SDH-B Mutation

Aidan McGowan, Julie Y. An, Sally Tanakchi, Mahir Maruf, Akhil Muthigi, Arvin George, Daniel Su, Maria J. Merino, W. Marston Linehan, Shawna L. Boyle, Adam R. Metwalli

Research output: Contribution to journalArticle

Abstract

Magnetic Resonance Imaging (MRI) and fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) are recognized approaches for locating paragangliomas. Recently, gallium-68 DOTA-octreotate (DOTATATE) scans have shown promise detecting neuroendocrine tumors missed by FDG-PET and MRI. 13-year-old male with SDH-B mutation presented with symptoms of paraganglioma and elevated catecholamines. MRI did not demonstrate the T2 hyper intense signal typical of paraganglioma and pheochromocytoma; FDG-PET scan did not reveal increased foci of uptake. DOTATATE scan revealed a signal consistent only with residual adrenal tissue. Resection of the right adrenal bed revealed paraganglioma. Following surgery, no further symptoms were reported and biochemical tests normalized.

Original languageEnglish (US)
Pages (from-to)107-109
Number of pages3
JournalUrology Case Reports
Volume13
DOIs
StatePublished - Jul 1 2017

Keywords

  • Adrenalectomy
  • Nephrectomy
  • Paraganglioma
  • Succinate dehydrogenase B mutation

ASJC Scopus subject areas

  • Urology

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    McGowan, A., An, J. Y., Tanakchi, S., Maruf, M., Muthigi, A., George, A., Su, D., Merino, M. J., Linehan, W. M., Boyle, S. L., & Metwalli, A. R. (2017). Multiple Recurrent Paraganglioma in a Pediatric Patient with Germline SDH-B Mutation. Urology Case Reports, 13, 107-109. https://doi.org/10.1016/j.eucr.2017.03.017