Multiple sclerosis

M. Patricia Leuschen, Kathleen M. Healey, Mary L. Filipi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

New therapies challenge the very definition of multiple sclerosis (MS). By classic definitions, MS is a chronic neurological disease characterized by plaques or scars in the central nervous system (CNS) as a result of demyelization and atrophy of neuronal axons. However, for most diagnosed with MS, symptoms and progression are much more heterogeneous than that definition would imply. For most with MS, the initial symptoms include a relapsing and remitting inflammatory phase (RR-MS), which responds to immunotherapy. Natural history studies of clinical relapse rates, a primary endpoint used in most phase III treatment trials, report incidence of relapses from 0.5 to 2 per year (Weinshenker and Ebers, 1987). With time, most RR-MS patients transition to what has been characterized as a non-inflammatory secondary progressive form of the disease (SP-MS). Immunotherapies that target the inflammatory phase of MS may not be effective once the transition occurs. In addition, a proportion of those diagnosed with MS exhibit a more aggressive form of MS that does not show significant remission cycles nor respond to the same therapies. This aggressive form of the disease was termed primary progressive (PP-MS) using consensus data from an international survey of clinicians for standard definitions of these common clinical MS courses (Lublin and Reingold, 1996).

Original languageEnglish (US)
Title of host publicationNeuroimmune Pharmacology
PublisherSpringer US
Pages589-603
Number of pages15
ISBN (Print)9780387725727
DOIs
StatePublished - 2008

Keywords

  • EAE
  • Gadolinium
  • Glatiramer acetate
  • IFNβ-1a
  • IFNβ-1b
  • Mitoxantrone
  • Natalizumab
  • Neuromyelitis optica
  • PASAT
  • Sclerosis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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  • Cite this

    Leuschen, M. P., Healey, K. M., & Filipi, M. L. (2008). Multiple sclerosis. In Neuroimmune Pharmacology (pp. 589-603). Springer US. https://doi.org/10.1007/978-0-387-72573-4_40