Multiple sclerosis and prostate cancer: What do their similar geographies suggest?

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

Mortality rates from multiple sclerosis show a well-known north-south gradient, both within the United States and internationally. Mortality rates from prostate cancer show a similar gradient and are significantly correlated with multiple sclerosis (MS) mortality and MS prevalence. This finding adds prostate cancer to the set of diseases whose geographic distributions are significantly correlated with MS and whose members include colon cancer, dental caries, and Parkinson's disease. Review of the literature indicates that these clinically dissimilar diseases may share an aberration in vitamin (hormone) D. Recent evidence demonstrating a multi-faceted role for vitamin D in immunoregulation suggests that a vitamin D aberration may also contribute to the etiology of MS. A vitamin D hypothesis can illuminate several unexplained features of the epidemiology of MS and suggests opportunities for epidemiologic, laboratory, and clinical investigation.

Original languageEnglish (US)
Pages (from-to)244-254
Number of pages11
JournalNeuroepidemiology
Volume11
Issue number4-6
DOIs
StatePublished - 1992

Keywords

  • Epidemiology
  • Geography
  • Hormones
  • Immunology
  • Multiple sclerosis
  • Prostate neoplasms
  • Therapeutics
  • Vitamin D

ASJC Scopus subject areas

  • Epidemiology
  • Clinical Neurology

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